Important Cytokines Flashcards Preview

Term 3: Immunology/Pathology > Important Cytokines > Flashcards

Flashcards in Important Cytokines Deck (24):
1

IL-1

=osteoclast-activating factor

-fever

-acute inflammation

-induce chemokine secretion, attract WBC's

2

IL-6

-fever

-stimulates production of acute-phase proteins

3

IL-8

-Main chemotactic factor for neutrophils

NEUTROPHILS

4

IL-12

-Activates NK cells

-Induces differentiation of T cells into Th1 cells

5

TNF-alpha

-WBC recruitment

-Mediates septic shock

-activates endothelium

-Cachexia (cancer)

6

Which cytokine causes Cachexia in malignancy?

-TNF-alpha

7

IL-2

-Stimulates growth of all T cells and NK cells

8

IL-3

-supports growth and differentiation of bone marrow stem cells

-functions like GM-CSF

9

Interferon-gamma

-Stimulates macrophages to kill phagocytosed pathogens

-Secreted by NK cells in response to IL-12

-Activates NK cells to kill virus-infected cells

-increase MHC expression and antigen presentation in all cells

10

IL-4

-Induces differentiation into Th2 cells

-Enhances class switching to IgE and IgG

-Promotes growth of B cells

11

IL-5

-Enhances class switching to IgA

-Stimulates differentiation of B cells

-Stimulates growth and differentiation of eosinophils

12

IL-10

-Modulates inflammatory response (secreted by Treg)

-Decreases expression of MHC II and Th1 cytokines

-Inhibits activated macrophages & dendritic cells

13

Which cytokines attenuate the immune response?

-TGG-beta

-IL-10

14

Which cytokines are secreted by macrophages?

IL-1

IL-6

IL-8

IL-12

TNF-alpha

15

Which cytokines are secreted by all T cells?

IL-2

IL-3

16

Which cytokines are secreted from Th1 cells?

-Interferon-gamma

17

Which cytokines are secreted from Th2 cells?

IL-4

IL-5

IL-10

18

IL-17

-massive recruitment of neutrophils

-helps against extracellular bacteria and fungi

(produced by (Th17)

19

IL-21

Growth factor for Th17 cells

(produced by Th17)

20

IL-13

-stimulates production of mucus in intestine

-prevents more pathogens from entering there

-produced by Th2 cells

21

Which cytokines stimulate Th2 cells?

IL-4

22

Which cytokines stimulate Th1 cells?

-INF-g

-IL-12

23

Which cytokines inhibit Th1 cells?

IL-4

IL-10

24

Which cytokines inhibit Th2 cells?

IFN-g (from Th1)