Important Cytokines Flashcards
Cytokine that causes fever and stimulates production of acute phase proteins
IL-6
Major chemotactic factor for neutrophils to clear infections
IL-8
Induces differentiation of T-cells into Th1 cells and activates NK cells
IL-12
Cytokine that activates endothelium and causes WBC recruitment and vascular leak
Tumor necrosis factor alpha (TNF-a)
Cytokine that causes fever, acute inflammation
IL-1
Cytokine that activates endothelium to express adhesion molecules and induces chemokine secretion to recruit WBCs
IL-1
Stimulates growth of helper, cytotoxic, and regulatory T-cells and NK cells
IL-2
Cytokine that functions like Granulocyte Macrophage - Colony Stimulating Factor (GM-CSF)
IL-3
Cytokine that promotes growth and differentiation of bone marrow stem cells
IL-3
Secreted by NK cells and T-cells in response to antigen or IL-12 from macrophages
Interferon-gamma (IFN-g)
Cytokine that stimulates macrophages to kill phagocytosed pathogens and inhibits Th2 differentiation
IFN-g
Cytokine that enhances class switching to IgE and IgG
IL-4
Cytokin that induces differentiation of T-cells to Th2 cells and promotes growth of B cells
IL-4
Cytokine that stimulates IgA production
IL-5
Cytokine that stimulates growth and differentiation of Be cells and eosinophils
IL-5
