Important Cytokines and Cell Surface Markers EC Flashcards Preview

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Flashcards in Important Cytokines and Cell Surface Markers EC Deck (19):
1

IL1-IL5 Functions

"Hot T-BONE stEAk"
IL-1=fever
IL-2=T cell proliferation
IL-3=Bone marrow stimulation
IL-4=IgE production
IL-5=IgA production

2

IL-1

Pyrogen (causes fever)
Acute inflammation
Secreted by macrophages

3

IL-2

Stimulate growth of T cells

4

IL-3

Support growth of bone marrow

5

IL-4

Induces Th2 differentiation
Promotes IgE glass switching

6

IL-5

Promotes B cell differentiation
Promotes production of IgA (Eonsinophils)

7

IL-6

Fever
Acute-phase protein

8

IL-8

Chemotaxis of Neutrophils

9

IL-10

Anti-inflammatory

10

IL-12

Th1 differentiation
NK activation

11

TNF-alpha

Septic shock
Leukocyte recruitment and vascular leak

12

Interferon-gamma

Activates macrophages, Th1, and NK cells
Increases MHC expression
Suppres Th2

13

What do Th1 cell secrete?

Interferron-gamma (activates macrophages, supresses Th2)

IL-2 (stimulate T-cells)
IL-3 (stimulate marrow)

14

What do Th2 cells secrete?

IL-4 (IgE, Th2 differentiation)
IL-5 (IgA, eosinophils)
IL-10 (inhibits Th1)

IL-2 (stimulate T-cells)
IL-3 (stimulates marrow)

15

Helper T cell markers

CD4, CD40L (CD4 only)

TCR, CD3, CD28 (all T cells)

16

Cytotoxic T cell markers

CD8 (CD8 only)

TCR, CD3, CD28 (all T cells)

17

B cell markers

Ig
CD19, CD20, CD21, CD40
MHCII, B7

18

Macrophage cell markers

CD14, CD40
MHCI, B7
Fc and C3b receptors

19

NK cell markers

CD56 (unique marker)
CD16 (binds Fc of IgG)