Important Oncogenes and Associated Cancers Flashcards Preview

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Flashcards in Important Oncogenes and Associated Cancers Deck (23)
1

Tumor(s) associated with PDGFB

Astrocytoma

2

Tumor(s) associated with ERBB2 (HER2/neu)

Subset of breast carcinomas

3

Tumor(s) associated with RET

MEN 2A, MEN 2B, and sporadic medullary carcinoma of thyroid

4

Tumor(s) associated with KIT

Gastrointestinal stromal tumor

5

Tumor(s) associated with RAS gene family

Carcinomas, melanoma, and lymphoma

6

Tumor(s) associated with ABL

CML and some types of ALL

7

Tumor(s) associated with c-MYC

Burkitt lymphoma

8

Tumor(s) associated with N-MYC

Neuroblastoma

9

Tumor(s) associated with L-MYC

Lung carcinoma (small cell)

10

Tumor(s) associated with CCND1 (cyclin D1)

Mantle cell lymphoma

11

Tumor(s) associated with CDK4

Melanoma

12

Gene product of ABL

Tyrosine kinase

13

Gene product of c-MYC

Transcription factor

14

Gene product of bcl-2

Anti-apoptotic molecule

15

Tumor(s) associated with bcl-2

Follicular and undifferentiated lymphomas (inhibits apoptosis)

16

Gene product of HER2/neu (c-erbB2)

Tyrosine kinase

17

Gene product of RAS

GTPase

18

Gene product of L-myc

Transcription factor

19

Gene product of N-myc

Transcription factor

20

Gene product of ret

Tyrosine kinase

21

Gene product of KIT

Cytokine receptor

22

Tumor(s) associated with BRAF

Melanoma

23

Gene product of BRAF

B-raf