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Flashcards in Important Scientists Deck (12)
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1

Mike Brown and Joe Goldstein

Worked out the structure of the LDL receptor in their study of familial hypercholesteremia. For this they won the Nobel prize

2

Barbara Pearse

Discovered that the coat on coated vesicles is made of a protein called clathrin. Clathrin consists of 3 copies of each of 2 proteins, arranged in a triskelion. Triskelions makeup the cages of clathrin-coated vesicles

3

Linda Buck

With colleagues, was the first to discover olfactory receptors, 1000s of G protein-coupled receptors (GPCRs) expressed in the nose olfactory bulb that detect different odors.

4

George Palade

Worked out the secretory pathway using pancreatic acinar cells. For this he received the Nobel Prize

5

Tim Mitchison and Mark Kirschner

Instrumental in discovering “dynamic instability,” the way in which microtubules grow and deploymerize. Also showed that Xenopus extract mitotic cytosol induces 5X the turnover rate of the microtubule’s GTP CAP (“Catastrophe”) as occurs in interphase cytosol.

6

Steve Hedrick

First, along with Mark Davis, to clone the T cell receptor subunits

7

Mike Bishop and Harold Varmus

Were the first to show that a viral oncogene, v-src, was really a normal cellular gene (c-src), that had been hijacked onto a virus and turned into an oncogene. (Additional mutations in the protein sequence were necessary to turn c-src into an oncogene). Received the Nobel prize for this.

8

Susumu Tonegawa

Discovered that antibody diversity stems in large part from combinatorial rearrangement of the Variable regions of the heavy chain gene of immunoglobulins. Received the Nobel Prize for this discovery.

9

Brian Druker

Developed Gleevec, the first treatment to block a cancer-causing kinase and kill cancer cells in chronic myeloid leukemia (CML). His type of treatment is referred to as a “magic bullet”

10

Liz Blackburn and Carol Greider

Won the 2009 Nobel Prize in Medicine for elucidating the structure and function of telomere sequences and discovering the enzyme that copies them, telomerase.

11

Zhongshen You

Showed that the kinase ATR monitors DNA replication forks and sends a signal that blocks activation of the mitotic kinase (CDK1/cylcin) until all DNA replication is complete

12

Lisa Stowers

Worked out how mice detect kairomones from rat, cat and snake, and discovered that the kairomones are proteins of the Mup family
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