Infection - Glycopeptides Flashcards
1
Q
what are glycopeptides?
A
dalbavancin, teicoplanin, tstevancin + vancomycin
2
Q
what is best route of adminstration for vancomycin
A
Parental for systemic infections as low absorption with oral routes
3
Q
can you give glycopeptides in pregnancy?
A
avoid unless benefit outweighs risk
4
Q
how is inital dose dose calculated in vancoymcin?
A
inital dose is based on body weight then adjusted according to vancomycin concentration
5
Q
what is trough level for vancomycin?
A
15-20mg/l
6
Q
What can glycopeptides cause?
A
ototoxicity and nephrotoxicity
7
Q
what are the s/e of glycopeptides?
A
- red man syndrome
- severe cutaneous adverse steven-johnson syndrome
- blood dyscrasia - agranulocytosis, eosinophilia + neutropenia
- cardiogenic shock on rapid IV inj
- risk of anphylactoid reactions at infusion site avoid rapid infusion and rotate site
