Infections-side effects

Question 1

Drugs that cause ototoxicity? (3)

Answer 1

1) Aminoglycosides e.g gentamicin, steptomycin etc
2) Glycopeptides e.g vancomycin, teicoplanin etc
3) Macrolides e.g erythromycin etc

Question 2

Drugs that cause renal impairment? (2)

Answer 2

1) Aminoglycosides

2) Glycopeptides

Question 3

Drugs that cause hepatic impairment? (7)

Answer 3

1) Macrolides
2) Flucloxacillin (cholestatic jaundice)
3) Co-amoxiclav (Cholestatic jaundice)
4) Nitrofurantoin (hepatitis)
5) Tetracylines (hepatotoxicity)
6) Clindamycin (jaundice)
7) Monoflaxacin (life-threatening hepatotoxicity)

Question 4

Drugs that cause tendon rupture?

Answer 4

Quinolones e.g ciproflaxacin, monoflaxacin etc

Question 5

Drugs that cause skin photo-sensitivity?

Answer 5

1) Tetracyclines

2) Quinolones

Question 6

Antibiotic that impairs driving?

Answer 6

Ciproflaxacin

Question 7

Antibiotic that can cause ‘red man syndrome’?

Answer 7

Vancomycin

Question 8

Antibiotics that are teratogenic? (3)

Answer 8

1) Trimethoprim, Co-trimazole
2) Aminoglycosides (ear damage)
3) Tetracylines (deposits in bones)

Question 9

Antibiotics that cause blood disorders? (2)

Answer 9

1) Trimethoprim, co-trimazole

2) Glycopeptides

Question 10

Drugs that cause esophageal irritation?

Answer 10

1) Tetracylines

2) Clindamycin

Question 11

Antibiotic that can cause a hypertensive crisis and why?

Answer 11

Linezolid- it is an MAOI

Question 12

Antibiotics that can cause CNS toxicity?

Answer 12

Penicillins

Question 13

Antibiotics that can cause visual disturbance? (2)

Answer 13

1) Tetracylines- STOP

2) Metronidazole (optic neuropathy-REPORT)

Question 14

Antibiotics that prolong the QT interval? (2)

Answer 14

1) Quinolones

2) Macrolides

Question 15

CYP450 inhibitors?

Answer 15

Macrolides e.g erythromycin, clarithromycin etc

Question 16

CYP450 substrate?

Answer 16

Metronidazole

Question 17

Antibiotics that cause hyperkalaemia?

Answer 17

Trimethoprim, Co-trimazole

Question 18

Antbiotic that can cause pulmonary reactions?

Answer 18

Nitrofurantoin (look out for difficulty breathing)