Infectious and Parasitic Diseases Flashcards Preview

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Flashcards in Infectious and Parasitic Diseases Deck (13):
1

Common viruses

Human T-cell lymphoma/leukemia virus (HTLV-1)
Epstein-Barr Virus
Hepatitis B and C
West Nile Virus
Human Papillomavirus

2

Types of Staphylococcus Aureus (SA) - 8
(common bacterial)

SA food poisoning
Methicillin-resistant SA (MRSA) infections
Enterocolitis
Pneumona
cellulitits
baterial arthritis
cellulitis
acute staphylococcal osteomyelitis

3

Types of Group A streptococcus (GAS) - 4
(common bacterial)

Pharyngitis
Rheumatic fever
Scarlet fever
Necrotizing fasciitis

4

Types of Group B Streptococcus (GBS) - 2

Sepsis
(25% of women are positive for GBS)

5

Creutzfeldt - Jacob Disease
- CS&S

Neuro disease caused by prion accumulation (hypertrophic)
- CSS: dementia, balance problems, paralysis, loss of speech

6

West Nile Virus
Etiology
CSS
Tx

Transmitted by mosqitos
CSS: fever, headache, body aches, jt p!, vomiting diarrhea or rash
Tx: no medication or vaccines

7

Epstein - Barr Virus (DNA virus) [tumor]
Etio
What does it target?
CSS
Implicated carcinoma?

- Etio: Spreads through bodily fluids (saliva) usually in childhood.

- EBV gene products stimulate B-cell proliferation

- CSS: fatigue, fever, inflamed throat, swollen lymph nodes, enlarged spleen, swollen liver, rash

Carcinoma: nasopharyngeal carcinoma

8

HTLV-1 (RNA virus) [tumor]
Which envolved protien?
Activates what genes?
Secondary mutation?

- Encodes for TAX (T) protein
- TAX pro activates expression of genes that encode cytoknies and cytokine receptors (cause inc T-cells)
- 2nd: can lead to leukemia

9

Hep B and C (DNA virus) [tumor]

Do not encode oncogenes
- Immune mediated chronic inflammation leading to hepatocyte death which triggers genomic dmg (neoplastic cells)

10

HPV (DNA virus) [tumor]

- Activates expression of oncoprotiens
- Low risk usually give rise to benign tumores
- High risk usually give stimulates mutations to regulatory genes involved in tumor progession

11

Helicobacter pylori [tumor]
- Gastric adenocarcinoma

Immune mediated chronic inflammation leading to gastric cell proliferation. Inc production of ROS and dmg DNA
- Gastric adenocarcinoma: contains H. pylori CagA gene

12

HTLV-1 vs Epstein-Barr

HTLV-1:
RNA virus
TAX protein increases cytokines which inc T-cells

Epstein-Barr:
DNA virus
EBV gene stimulates B-cell proliferation

13

Hep B and C vs HPV

Hep B and C:
DNA
Do not code oncogenes
(chronic inflammation in hepatocytes ----> triggers genomic dmg, develop neoplastic cells)

HPV:
DNA
Activates expression of oncoproteins
(too much replication gives rise to tumors)