Infectious Disease Flashcards Preview

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Flashcards in Infectious Disease Deck (36):
1

Most common pathogen of Necrotizing Fasciitis

Group A Strep (NOT staph aureus)

2

Disease that AIDS pts. can get from birds/pigeons
Dx
Tx

Cryptococcal meningitis (budding yeasts on India ink)
LP
Amphotericin B and Flucytosine

3

Describe erysipelas.
Causative pathogen
Tx

Raised, erythematous area with noted demarcation and painful to touch
Strep pyogenes (Group A strep)
PCN

4

Henoch Schonlein Purpura
Tx

Type 3 H.S. small vessel vasculitis in children d/t IgA complexes presenting as purpura in buttocks, hematuria, and proteinuria.
Supportive care (hydration, rest, pain management)

5

Neutropenic Fever: What should you give if the fever doesn't resolve with empiric antibiotics (Anti-pseudomonals)?

Amphotericin B anti-fungal

6

Post-Herpetic Neuralgia tx.

Nortriptyline is 1st line (Pregabalin is 2nd line)

7

Type I H.S. (anaphylaxis, asthma, urticaria/hives)

Mechanism

Ag cross links IgE on Mast and Basophils thereby releasing Histamine

8

Type II H.S. (Autoimmune Hemolytic Anemia, Erythroblastosis Fetalis, Goodpasture Syn, Rheumatic Fever)

Mechanism

Cy-2-toxic process where IgM and IgG bind to Ag on enemy cell to form Membrane Attack Complex or phagocytosis

9

Type III H.S. (Polyarteritis nodosa, SLE, Rheumatoid Arthritis, Serum sickness, Arthus rxn)

Mechanism

Ag-Ab complexes activate complement and attract Neutrophils which then kill with lysozymes

10

Type IV H.S. (Delayed type, Mantoux test, Transplant rejection, Contact dermatitis)

Mechanism

T lymph are sensitized and when triggered, release lymphokines to activate macrophages

11

Most common pathogen in nosocomial acquired G(-) bacteremias.

Tx?

Enterobacter

Ertapenem

12

Tetanus Management Clean minor wound:

Unknown vacc. hx or 10 yrs since last dose. Otherwise nothing.

13

Tetanus Management NON-minor wound:

Unknown vacc. hx or 10 yrs since last dose. Otherwise nothing.

14

Tx. of Mucor

Amphotericin B + Surgical debridement

15

Dx. Hydatid cyst (Echinoccocus)

US + serology

16

Tx. for Local Tetanus

Tetanus Ig
Metronidazole
Benzodiazepine (like Diazepam)

17

Tx. for Methicillin-Sensitive Staph Aureus (MSSA)

Cefazolin

18

Tx. of Coagulase-Negative Staph bacteria

Vancomycin empirically

19

Histoplasmosis

Ohio River Valley
Diffuse bilateral nodular densities
Hilar lymphadenopathy

Tx: IV Amphotericin B then Itraconazole x 12wks

20

Blastomycosis (Broad Based Budding)

South Central US
Flu-like illness
Violaceous papules with crusting

21

When is PCV13 (pneumococcal vaccine 13 valent given)?

for 65+ y.o. then do PPSV23

22

When is PPSV23 vaccine given?

1 time vaccine

23

Salmonella keywords

G(-) rod MOTILE ("salmon swim") with flagella
Lactose Non-fermenter
H2S +
upregulates cAMP

Tx: Quinolone, TMP-SMX

24

Shigella keywords

G(-) rod NONMOTILE
Lactose Non-fermenter
H2S (-)
protein synthesis inhibiting toxin
daycare

Tx: Azithromycin, Ciprofloxacin

25

Tuberculosis keywords

Acid Fast
Non-calcified round opacities
Cavitation of upper lobe is "advanced TB"

26

What herbal remedy should be avoided in a pt. taking HAART?

St. John's Wort. It increases metabolism of protease inhibitors.

27

Sarcoidosis pathophysiology

macro --> 1-a-hydroxylase (which converts Vit D to active 1,25...) thus increasing Ca absorption

28

AIDS Opportunistic Infections at 200-500 CD4

Prophylaxis?

Candidiasis
HSV
Kaposi
TB (Ppx: Isoniazid x 9mo)
Varicella

29

AIDS Opportunistic Infections at 100-200 CD4

Prophylaxis?

Pneumocystis Jirovecii pneumonia

Ppx: TMP-SMX single strength

30

AIDS Opportunistic Infections at 50-100 CD4

Prophylaxis?

Coccidioidomycosis
CryptoSPORIDIUM
Histoplasma
Toxoplasmosis (Ppx: TMP-SMX 2x strength)

31

AIDS Opportunistic Infections at

CMV retinitis
CNS Lymphoma
CryptoCOCCUS
MAC (Ppx: weekly Azithromycin or weekly Clarithromycin)

32

Rheumatic Fever Criteria

Dx?

Joints

33

Graft V. Host Disease (Type IV H.S.)

T cells from DONOR attack the HOST's cells

34

Tx. Vibrio cholerae gastroenteritis

Azithromycin (macrolide), Tetracycline, or Fluoroquinolone + Oral rehydration

35

Cryptococcal Meningitis keywords

HIV pt.
budding yeasts on India ink
pigeons

Tx: Amphotericin B and Flucytosine

36

Primary Amyloidosis keywords

proteinuria
heavy lambda-light chains
apple green birefringence after K+-permanganate