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Flashcards in Infectious Disease I Deck (449)
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1

Penicillins MOA

beta-lactams that inhibit bacterial cell wall synthesis

2

Penicillins exhibit ______ dependent killing

time

3

Penicillins are bacterio_______

bactericidal except against enterococci species (requires aminoglycosides for cidal activity)

4

Boxed warning of Penicillin G benzathine

Not for IV use, can cause cardiorespiratory arrest and death

5

Penicillin brand name

Pen VK

6

Penicillin dosing

125-500 mg PO Q6-12H on an empty stomach

7

Penicillin G Benzathine brand name

Bicillin LA

8

Penicillin G Benzathine dosing

1.2-2.4 million units IM x 1 (frequency varies)

9

Pen G Procaine brand name

Bicillin CR

10

Pen G Procaine dosing

1.2-2.4 million units IM x 1 (frequency varies)

11

Penicillin G aqueous brand name

Pfizerpen-G

12

Penicillin G aqueous dosing

2-4 million units IV Q4-6H

13

Augmentin contraindication

history of cholestatic jaundice of hepatic dysfunction associated with previous use; severe renal impairment (CrCl

14

Unasyn contraindications

history of cholestatic jaundice or hepatic dysfunction associated with previous use; severe renal impairment (CrCl

15

Warnings for all penicillins

Anaphylaxis/hypersensitivity reactions. Do not use in penicillin allergic patients

16

Side effects of all penicillins

GI upset, diarrhea, rash, allergic reactions, anaphylaxis, acute interstitial nephritis, myelosupression with prolonged use, increased LFTs, seizures with accumulation

17

Monitoring for all penicillins

Renal function, symptoms of anaphylaxis with 1st dose, CBC and LFTs with prolonged courses

18

Natural penicillins spectrum of activity

Streptococci, Enterococci, gram positive anaerobes (mouth flora)

19

Aminopenicillins spectrum of activity

streptococci, enterococci, HNPEK, gram positive anaerobes (mouth flora)

20

Aminopenicillins/beta-lactamase inhibitor combos spectrum of activity

MSSA, more resistant HPNEK, gram negative anaerobes (B. fragilis)

21

Amoxicillin brand names

Amoxil, Moxatag

22

Amoxicillin/calvulanate brand name

Augmentin, Augmentin ES 600, Augmentin XR, Amoclan

23

Amoxicillin dosing

250-500mg PO Q8H or 500-875 mg PO Q12H, or 775 m XR (moxatag) PO daily

24

Amox/clav dosing

*Use 14:1 ratio to reduce diarrhea*, 500 mg PO TID, 875 mg PO BID, or 2000 XR PO BID with food

25

Ampicillin dosing

250-500 mg PO Q6H on an empty stomach 1 hour before or 2 hours after meals or 1-2 grams IV/IM Q4-6H

26

ampicillin/sulbactam brand

Unasyn

27

amount of each component in unasyn 3 g

2 g ampicillin / 1 g sulbactam

28

ampicillin/sulbactam dosing

1.5-3 grams IV Q6H

29

Extended spectrum penicillins spectrum of activity

streptococci, MSSA, enterococci, more resistant strains of HPNEK, CAPES, gram positive anaerobes (mouth flora), and gram negative anaerobes (B. fragilis), Pseudomonas

30

Piperacillin/tazobactam brand name

Zosyn