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Flashcards in Inflamation Deck (19):
1

What are the 5 triggers of inflammation.

1) foreign body
2) infection
3) ischaemia
4) physical or chemical injury
5) immune reaction

2

Why is inflammation good

Limits tissue injury
Removed dead tissue
Promotes specific immunity
Prepares and initiated for healing and repair

3

When is inflammation bad

Allergies

4

What is involved in inflammation

Fluid and proteins
Circulating blood cells
Blood vessels
Constituents of connective tissue

5

What is a vascular reaction

Increase in vascular permeability = change in flow + vessel calibre occurs to max the movement of plasma proteins and circulating cells to the injury

^ blood flow ^ pressure @ vessels = cells and proteins leak

6

What is a cellular reaction

WBC extraversion x3 stages
1) margination- cell rolls to activated endothelium
2) transmigration- attaches to walk
3) migration through tissue

7

WhT are the 3 steps of phagocytosis

1) recognition
2) engulfment
3) killing

8

What are the cardinal signs of inflammation

Redness
Swelling
Heat
Loss of function
Pain

9

What are the general symptoms of phagocytosis

Fever
Increased bp + hr
Increased wbc + crp

10

What is acute inflammation

Rapid response short lived
Neutrophils predominantly resolve
Complete resolution healed by fibrosis
E.g burn or infection

11

What is chronic inflammation

Prolonged inflammation that can develop from acute or persistent infection, prolonged exposure to toxins, autoimmune.
Lymphocytes or macrophages predominant

12

What meds can be used to manage inflammation

NSAIDs
Anti histamine
Steroid

13

What are x3 negatives to lack of inflammation

Susceptible to infection
Delay in wound healing
Tissue damage

14

5 markets of appendicitis

1) 10-30 years old
2) pain localised to right iliac
3) pain worse when move and can cause vomiting
4) Pyrexia increased hr increased wbc increase crp
5) complications = perforation = abscess

15

What 4 things cause immune system deficiency

1) chemotherapy drugs
2) hiv
3) splenectomy
4) bone marrow dysfunction

16

How does hiv work

. Affects cd4 & T cells causing aids.
Body = opportunistic for infection

17

What are secondary causes of immunodeficiency

Malnutrition
Burns
Uraemia
Diabetes
Immunotoxic meds
Recreational drug use

18

What is autoimmunity

Failure of an organ to recognise its own parts as itself

19

5 autoimmune diseases

Diabetes
Coeliac
Muscular sclerosis
Hashimotos tyroidutis
Rheumatoid arthritis