Flashcards in Inflammation Deck (14):
What promotes prostaglandin release?
Types of Eicosanoids?
Prostaglandins, thromboxanes, and leukotrienes
What type f cell cannot make eicosanoids?
What are eicosanoids derived from?
Arachadonic Acid (from Linolenic) or EPA (from Linoleic)
Precursor associated with inflammation? Anti-inflammatory response?
Arachadonic Acid. EPA.
Who cleaves/releases arachadonic acid?
Formation of what structural feature is required for AA activity?
Difference/Similarity between Asprin and Ibuprofen
Both NSAIDS. Asprin is irreversible and ibuprofen is reversible competitive.
What does Cox 1 do?
What does Cox 2 do?
Inducible response to pain. NSAID target
What do glucocorticoids do to the prostaglandin pathway?
Inhibit Phospholipase A2
Two Products of Prostaglandin?
Prostaglandin (PGI2) and Thromboxane (TXA)
What does prostacyclin do?
Inhibits platelets aggregation