Inflammation Flashcards Preview

Bryochemistry Last Exam > Inflammation > Flashcards

Flashcards in Inflammation Deck (14):
1

What promotes prostaglandin release?

Inflammation

2

Types of Eicosanoids?

Prostaglandins, thromboxanes, and leukotrienes

3

What type f cell cannot make eicosanoids?

RBC

4

What are eicosanoids derived from?

Arachadonic Acid (from Linolenic) or EPA (from Linoleic)

5

Precursor associated with inflammation? Anti-inflammatory response?

Arachadonic Acid. EPA.

6

Who cleaves/releases arachadonic acid?

Phospholipase A2

7

Formation of what structural feature is required for AA activity?

C15 Hydroxyl

8

Difference/Similarity between Asprin and Ibuprofen

Both NSAIDS. Asprin is irreversible and ibuprofen is reversible competitive.

9

What does Cox 1 do?

Physiological Housekeeping

10

What does Cox 2 do?

Inducible response to pain. NSAID target

11

What do glucocorticoids do to the prostaglandin pathway?

Inhibit Phospholipase A2

12

Two Products of Prostaglandin?

Prostaglandin (PGI2) and Thromboxane (TXA)

13

What does prostacyclin do?

Inhibits platelets aggregation

14

What does thromboxane do?

Stimulates platelet aggregation and vasoconstricts