Inflammation #4 (Murnane) Flashcards Preview

Musculoskeletal Disorders and Pain Management > Inflammation #4 (Murnane) > Flashcards

Flashcards in Inflammation #4 (Murnane) Deck (19):
1

humoral immunity (antibody mediated)

b cells

2

cellular immunity (cell mediated)

t cells

3

antigens

mobilize adaptive defense AND provoke an immune response

4

T/F Most complex antigens ARE NOT found in the body (non self)

TRUE

5

T/F Antigen presenting cells RESPOND to SPECIFIC antigens

FALSE; DO NOT

6

primary lymphoid organs (2)

-red bone marrow= b cells
-thymus= t cells

7

antibodies

AKA immunoglobulins
proteins secreted by plasma cells

8

What region of the antibody is VARIABLE?

FAB

9

What region of the antibody determines the CLASS?

Fc or constant region

10

T/F Antibodies DESTROY antigens

FALSE; they form complexes instead to inactivate the antigen

11

What are the defensive mechanisms used by antibodies? (2)

-neutralization and agglutination (clumping)
-precipitation and complement fixation

12

T/F B cells can switch antibody classes, BUT retain antigen specificity

TRUE

(isotope switching) First they are IgM, then change to IgG (almost all secondary responses are IgG)

13

T/F T cells (CD4) activate B cells

TRUE

14

Antibodies cause _____ and _____ hypersensitivities

immediate AND subacute

15

T cells cause ______ hypersensitivity

delayed

16

What do you use to treat anaphylactic shock?

Epi (alpha 1) and steroids

17

Which pathway attracts neutrophils to the site of inflammation?

alternative pathway

18

T/F Haptens are immunogenic

FALSE: only when they are attached to body proteins and combination is marked foreign

19

Which cytokines can induce COX-2 (3)

-TNF
-IL-2
-IL-6