Inflammation Drugs Uses and Side effects Flashcards Preview

Pharm Unit 2 MJC > Inflammation Drugs Uses and Side effects > Flashcards

Flashcards in Inflammation Drugs Uses and Side effects Deck (13)
1

Acetylsalicylic Acid (ASA, aspirin)

Use: Antiplatelet, analgesic and antipyretic, antiinflammatory (at high doses); often taken as baby aspirin to preven MI and CVA

SE: GI irritation, bleeding and anemia, hepatoxicity, and salicylate toxicity. Nephrotoxicity in elderly or hypovolemic pt

2

Diflunisal

Use: Osteoarthritis, MSK strains/sprains, pain after dental extraction, postepisiotomy pain. Better than aspirin for inflammatory conditions

SE: Fewer GI side effects and less platelet effects than aspirin.

3

Acetaminophen (tylenol)

Use: Analgesic and antipyretic effect similar to aspirin but weak anti inflammatory effects

SE: renal tubular necrosis if chronically abused; hepatic necrosis with overdose. Less GI irritation than aspirin

4

Indomethacin

Use: rheumatoid arthritis (10x as potent as aspirin), ankylosing spondylitis, osteoarthritis, acute gout

SE: At times, thrombocytopenia, aplastic anemia, severe frontal headaches, nephrotoxicity in elderly and hypovolemic. Toxicities cause 25% of pt to stop

5

Sulindac

Use: Rheumatoid arthritis (half as potent as indomethacin) ankylosing spondylitis, osteoarthritis, acute gout

SE: At times, thrombocytopenia, aplastic anemia, severe frontal headaches, nephrotoxicity in elderly and hypovolemic.

6

Ibuprofen

Use: Rheumatic disorders, osteoarthritis, ankylosing spondylitis, postpartum pain, dysmenorrheal pain, and many types of surgeries

SE: GI irritation; hepatotoxicity (less frequent than aspirin)

7

Flurbiprofen

Use: Rheumatic disorders, osteoarthritis, ankylosing spondylitis, postpartum pain, dysmenorrheal pain, and many types of surgeries, obtains high synovial concentration

SE: GI irritation; hepatotoxicity (less frequent than aspirin)

8

Naproxen

Use: Rheumatic disorders, osteoarthritis, ankylosing spondylitis, postpartum pain, dysmenorrheal pain, and many types of surgeries

SE: GI irritation; hepatotoxicity (less frequent than aspirin)

Longer T1/2 13 hrs

9

Oxaprozin

Use: Rheumatic disorders, osteoarthritis, ankylosing spondylitis, postpartum pain, dysmenorrheal pain, and many types of surgeries

SE: GI irritation; hepatotoxicity (less frequent than aspirin)

Very long T1/2 50 hrs

10

Piroxicam

Use: Long term treatment of rheumatoid arthritis or osteoarthritis; also, ankylosing spondylitis, acute MSK disorders and gout

SE: same as aspirin

Very long T1/2 45 hrs permits once daily dosing

11

Ketorolac

Use: Post operative pain; inflammatory eye conditions

SE: same as aspirin

Injectable equally or more efficacious than morphine T1/2 4-6hrs

12

Celocoxib

Use: same as other NSAIDs

SE: less GI toxicity

Contraindicated in patients with heart problems or pregnancy

13

Etoricoxib

Use: same as other NSAIDs

SE: less GI toxicity

Contraindicated in patients with heart problems or pregnancy