Inflammation Pharm

Question 1

Aspirin, Ibuprofen, Naproxen, Indomethacin, and Diclofenac are all ______s

Answer 1

NSAID

Question 2

NSAIDS inhibit the _____ enzyme, by binding to Arachidonic acid and not allowing it to be converted

Answer 2

COX-2

Question 3

What is special about Asprin’s binding mechanism?

Answer 3

It’s Irreversible!

Question 4

Bradykinin _____ the blood pressure and stimulates pain receptors

Answer 4

Lowers

Question 5

The main prostanoid in inflammation is PG_____

Answer 5

E2

Question 6

The Eicosanoid _____ Promotes thrombosis and vasoconstricts (Opposite of PGI2)

Answer 6

TXA2

Question 7

Selective COX-2 Inhibitors increase the risk of _____, because there’s a slight excess of _____

Answer 7

Thrombosis, TXA2

Question 8

Prostaglandin _____ promotes gastric mucus secretion and inhibits acid secretion; PROTECTION, but also INFLAMMATION everywhere else

Answer 8

E2

Question 9

Cox____ maintains homeostasis while Cox_____ is more involved with inflammation

Answer 9

1, 2

Question 10

A reduction in “housekeeping” prostaglandins like PGE2 protecting the stomach gets wrecked by too much _____, that’s why people with ulcers are not reccomended to take this medicine

Answer 10

Aspirin

Question 11

_____ not an NSAID, but has anti-pyretic and analgesic properties; over-dose can happen at 2-3 times of Tx and get NAPQI

Answer 11

Acetaminophen

Question 12

Blocking COX1 and COX2 with NSAIDs causes a buildup of Arachidonic acid and causes it to be acted on by _____ to get Leukotrienes LTC4, LTD4, LTE4 for “4llergic” reactions

Answer 12

5-Lipoxygenase

Question 13

Prostaglandin _____ INHIBITS clots and vasodilates (opposite of TXA2)

Answer 13

I2 (Prostacyclin)