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Flashcards in Influenza Deck (10)
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1

Pathophysiology

Spread: droplet
Incubation: 1-4d
Infectivity: 1d before symptoms start to 7d after
Immunity: only strains which have already attacked pt

2

Presentation

Fever
Headache
Malaise
Myalgia
N/v
Conjunctivitis

3

Complications

Bronchitis
Pneumonia: esp. Staph
Sinusitis
Encephalitis
Pericarditis
Reyes: rash, vomiting, ↑LFTs in children give aspirin

4

Ix

Bloods: lymphopenia,
thrombocytopenia
Culture: 1wk from nasal swabs
PCR: takes 36h

5

Mx

Bed rest + paracetamol

If severe:
- ITU
- Cipro and co-amoxiclav: prevent Staph and Strep
- Oseltamivir
- Neuraminidase inhibitor

Zanamivir:
Inhaled NA inhibitor active

6

Prevention

Good hygiene
Trivalent Vaccine

7

Who is offered the flu vaccine

>65yrs
DM, COPD, heart, renal, liver failure
Immunosuppression: splenectomy, steroids
Medical staff

8

Haemagglutinin

Surface antigen which binds to cells of infected person

9

Neuraminidase

Surface antigen that releases the virus from the host cells

10

Genetic variance

Life cycle 6 hrs
High error rate as no viral RNA polymerases
Causes antigenic drift