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Flashcards in Influenza & Parainfluenza Deck (77):
1

___ immunity is subtype specific

Humoral

2

HEF protein is the only spike protein contained in Influenza Type

C

3

Inactivated vaccine usually trivalent dapat composed of;

H3N2, H1N1, B

4

Interferon induction occurs in influ bc of

CMI response

5

Alberta Duck H1N1 Type A 35th strain found in 1976

A/ Duck/ Alberta/ 35/ 1976 (H1N1)

6

Classification of Influ A depends on which type of ___ associate together

HA and NA

7

Which is not a complication of Influenza
Acute otitis media; Bronchiolitis; Croup; Sinusitis; Myositis; Pneumonia; Reye syndrome

None of those mentioned

8

Highly pathogenic H5 virus reassorted its genome with those of other influ viruses in ____-> spread to poultry, humans, pigs

Aquatic birds

9

Which glycoprotein cleaves sialic acid on glycoproteins and removes it from host cell permitting virus dissemination

NA

10

Reye syndrome involves

encephalitis; febrile seizures

11

Importance of vaccine

Herd immunity

12

Amantadine and Rimantadine are ____ inhibitors that has NO effect on Influenza B and C and prevents UNCOATING and VIRAL RELEASE

M2 Proton channel

13

Influenza A and B every 10-40 years cause seasonal epidemics before being replaced by a different variant

Antigenic drift

14

All are influ hosts, plus
Whales, Waterfowls, Horses, Humans, Pigs, Seals,

Birds

15

Antigenic shift occurs through introduction of immunologically distinct __ & ___ molecules in a new human virus

HA, NA

16

Pandemics are due to antigenic ___ of ___

HA

17

Most specific lab diagnosis for Influ; best predictor of susceptibility of infection;
Positive result: Absence of agglutination since Abs in serum inhibits agglutination property of virus

Neutrlization test/ HA-inhibition

18

Which is not a transmission factor for Parainflu
A. Respi droplets
B. Airborne
C. Direct contact
D. indirect contact

A

19

Killed whole virus are inactivated virus vaccine grown in; killed virus injected to muscle

embryonated eggs

20

Immunity dependent upon localized anti-viral secretory IgA which is _____ compared to long lasting anti-viral serum IgG

strains specific and short-lived

21

Influenza matures by _________ at the _______;
A. budding, cytoplasm,
B. replication, cytoplasm
C. budding, cell membrane
D. replication, cell membrane

C

22

Serology of influ uses

paired sea, acute and convalescent

23

Most of symptoms of Influ affect ___ like RSV

Lower Respi Tract

24

Guillian Barre syndrome is a risk in vaccines for influ

T

25

Hongkong flu

H3N2; antigenic shift from H2N2

26

Treatment for parainflu

on my own

27

How many serologic types Parainfluenza

4

28

Which among these are not part of specimen used in influ
A. Gargle
B. Lavage fluid from bronchioles and alveoli
C. Nasal aspirate
D. Nasopharyngeal swab
E. none of the above

E.

29

Synthetic

neutralising epitope that's stable and can be used as universal vaccine

30

Seal bark cough; stridor

infections in kids of parainflu; 2-7 days after infection

31

Match
HA:3::NA:_

4, tetramer

32

Principal differential caused by H influ

Epiglottitis

33

Antigenic shifts happen to Influenza A only

T

34

H9N2

1999; Mild disease complete recovery of all patients

35

Parainflu grows well on

primary monkey kidney cells

36

For isolation of influenza use the following eggs and cels

embryonated; pirmary monkey kidney cells and madlindarby canine kidney cells

37

Match the NA inhibitors
Zanamivir, Osteltamivir to Tamiflu and Relenza

ZROT

38

Which among Influ types cause mild febrile illness

Type A

39

Which is not a property of Parainfluenza
A. Linear
B. Negative-sense
C. Segmented
D. Single stranded
E. Icosahedral nucleocapsid

C. Non-segmented dapat siya which makes it different from Segmented Influ;
E. Helical- same with Influ

40

Signs and symptoms of influ appear ___ after infection

1-4 days

41

Bird flu

2003; species specific, infected humans on rare occasions

42

Why do B and C have diff nomenclature (without origin and subtype)

few HA and NA types

43

Possible source of H5N1

Infected cickens

44

Which is not true abt transmission for Influ
A. Respiratory droplets
B. Direct contact
C. 10 000 to 100 000 000 virons per droplet

C. 100k to 1 M dapat

45

ParainfluenzaSerotypes 1-3 do not cause viremia

T

46

All pandemics are due to antigenic drift

F, shift dapat

47

Ab to NA

decrease severity

48

Which serologic type of Parainflu is assoc with bronchiolitis, bronchitis and pneumonia; during summer months

HPIV 3

49

Asian flu 1957

H2N2; antigenic shifts bw wild ducks and people

50

Tissue that makes host hospitable to growth of certain viruses or bacteria

Tissue tropism

51

Spanish flu 1918/Russian 1977

H1N1; Russian influe = NO pandemic

52

Syncytia formation

characteristic of Parainflu, formed when v protein mediates fusion of cells with neighboring cells

53

Breastfeeding may protect babies from HPIVs due to

protective Abs in mother's milk

54

NICHE, other methods of lab diagnosis

NT, IF, CF, HI, Elisa

55

Which is not one of the most common subtype of Influenza Type A?
A. H1N1
B. H2N2
C. H3N2
D. All are most common

B.

56

CMI; which ensures cross protection when memory T cells are reactivated

CD8 cytotoxic T cells

57

Which is not a function of HA glycoprotein
A. HAtion of human, horse RBCS
B. Neutralizing Ab response
C. Viral attachment and fusion protein
D. fusion of envelope to membrane at ACIDIC pH

A, dapat human, chicken, guinea pig

58

Types of Influenza based on these 2 antigens

RNP, M

59

Which among these do not undergo antigenic drift
A. Type A
B. Type B
C. Type C
D. None of the above

D. Lahat sila pero B&C do not undergo SHIFTS

60

Which is a factor in innate resistance
Mucociliary escalator, Surfactants that bind virions, alveolar macrophages

All of those mentioned

61

weakened influ virus sprayed into nose

Live virus, LAIV

62

HA from recombinant virus

Virus subunit

63

These are what causes antigenic drift

Point mutations

64

nebulized cold or hot steam and drinking Acetaminophen and ibuprofen is management for

Parainflu

65

Laryngotracheobronchitis other name

CROUP; most common manifestation of parainfluenza virus

66

Epidemics are due to antigenic ___ of ___

HA, NA

67

Genetic Reassortment would include 2 strains infecting a single host together; produces the almost the same new strains

F, different na

68

Incubation period Influ

18-72 hrs

69

What is the unique characteristic of Influ life cycle

snatches 5 prime gap

70

Upper respi tract

most commonly affected by Parainflu

71

as prophylaxis for people with allergy to vaccine

Amantidine

72

Swine flue

2009; H1N1, Mild Pandemic

73

Which is not part of envelope of Parainflu:
F, G, H, HN, VP1

VP1

74

Ab to HA

protective

75

Club cell function in pathogenesis of Influ

in respi tract; has enzyme that cleaves HA that facilitates entry of virus inside epithelial cell

76

which glycoprotein in Parainflu cause formation of syncytia

F

77

M2 Ion channel fucntion

promotes release of genome for entry into nucleus