Influenza Pharm

Question 1

Oral Oseltamivir

Answer 1

neuraminidase inhibitor

Tamiflu

treat acute influenza A and B infection

can only have sx 48 hours or less

don’t use dialysis or ESRD, or psych issues

can cause serious bacterial infections

don’t give flu vaccine within 2 weeks or 48 hours after oseltamivir is given–>interfere with effectiveness of vaccine

not a sub for early vaccination

not an inhibitor of CYP450

Question 2

Inhaled Zanamivir

Answer 2

neuraminidase inhibitor

Relenza

use influenza A and B infections

don’t use with lactose or milk protein allergy, psych, CV, COPD

eliminated from body via kidney, no metabolic biotransformation

Question 3

IV Peramivir

Answer 3

neuraminidase inhibitor

tmt of flu 18+

can have reaction similar to stevens-johnson syndrome–>erythema multiforme

can give after dialysis with renal impairment patients

Question 4

Baloxavir

Answer 4

polymerase acidic endonuclease inhibitor (inhibits viral mRNA replication)

risk of bacterial infection

Question 5

Amantadine

Answer 5

interferes with fx of transmembrane domain of viral M2 protein

doesn’t interfere with immunogenicity of inactivated influenza A vaccine (unlike other flu drugs)

also given with L-DOPA in Parkinson’s patients

10-14 hour half-life but renal impairment increases to 7-10 days