Flashcards in Inhalants Deck (16):
how is anesthetic [ ] controlled?
the potency is directly linked to lipid solubility,
explain the concentration vs. partial pressure vs. tension of inhalants
 of drugs in the alverolar air and tissues are different, but the tension and Partial pressure (Pa) are the same. At equilibrium; alveolar, blood, and brain anesthetic partial pressures are the same. this influences the delivery of volatile anesthetics.
the delivery of inhalants from alverolar gas to blood to brain depends on several factors. Name them
1. solubility of drug in tissues (Blood:Gas Partition Coefficient)
2. concentration of anesthetic in inspired air
3. ventilation rate
4. pulmonary blood flow
the more insoluble a drug is the more likely you are to ______? why?
recover and onset quicker.
1. effect related to partial pressure, and low  of poorly soluble drug with create ^ partial pressure
2. saturation rate of drug into tissues.
recovery is (longer/short) from a highly soluble anesthetic?
longer, because it takes longer to lower the blood concentration.
how are inhalants eliminated?
mainly by exhalation and also by respiratory rate and pulmonary blood flow.
poorly soluble drugs leave tissues faster-> fast recovery
what is the metabolic pathway of inhalants?
extent of metabolism is related to toxicity
metabolites are harmful to liver, and usually only a problem with long, repeated exposures to halothane, or long procedures with sevoflurance
What is MAC>
minimum alveolar concentration
used to compare potency of inhalent anesthetic. MAC50 is the concentration in inspired air that will prevent 50% of patients from feeling painful stimulus.
the more potent a drug is; the (more/less) concentration is needed?
describe the inhalant halothane
less used now, metabolites= cause liver damage
what are physiological effects of halothane?
1. depresses tidal volume (depth)
2. depresses the myocaridum (decrease in CO)
3. increases sensitivity of myocardium to epinephrine -> can cause arrhythmia
**must be careful wtih this inhalant and the thermoregulation of a patient.
what is malignant hyperthermia?
perople have mutated Ca2+ release RYR in skeletal muscle, halogen inhalant causes uncontrolled muscle contraction and increased body temp -> brain damage.
treated with muscle relaxant dantrolene
what is the toxicity of halothane?
-metabolites are hepatotoxic. they are called trifluoroacetic acids, and bind to hepatic proteins------> hepatitis
-can also cause valves on machines to malfunciton
what is isoflurane a more commonly used inhalant?
1. no hepatic or renal toxicity
2. low solubility
2. less depression of caridac output, but has dose-dependent drop in BP
4. less potent
5. highly stable
6. pungent odour :(
7. has much higher SSM (safety margin) than Halothane
what is sevoflurance?
second most used- similar to isoflurance
even less soluble
lack of odour- great for kids
no dangerous metabolites
BUT is less table than isoflurance and breaks down when exposed to CO2 absorbants, and not great for long procedures.