Flashcards in Innate & Acquired Imm System Deck (26):
Are B & T cells from Lymphoid or Myeloid precursors?
What is the most abundant class of antibody 75%
What is the first antibody to be made
Summarise what a B cells function is
Presents antibody immunoglobulin on cell surface - if antigen (eg on bacteria virus) matches it, the B cell will proliferate, making clones = antibody factories.
These antibodies attach to the bact antigen & "flag" it for destruction by macrophages.
Where are class 1 Major Histocompatibility Complexes (MHC) found & what do they do?
Surface of human cells, - "flag" to Killer T Cells that they are infected - killer T cell causes cell apoptosis.
Where are class 2 Major Histocompatibility Complexes (MHC) found & what do they do?
Outside of macrophages - present pathogen antigen to Helper T cells which create cytokines - furthering immune response.
The process of ensuring immature B cells do not recognise "self" which involves either Receptor editing or Anergy and occurs in bone marrow is what
What is anergy
B cell is only mildly self recognising so is down graded and becomes unresponsive.
What is receptor editing
B cell antibodies that recognise self either change to new ones or apoptosis.
Process of continuing to ensure B cells do not recog self and occurs in 2ary lymph tissue is what
This immunoglobulin is the first to be created on virgin B cells
This immunoglobulin binds to invaders and opsonizes for phagocytes - most common Ig
This immunoglobulin found at mucosal surfaces and breast milk
This immunoglobulin prod in response to specific allergens and cause mast cells to degranulate
What type of cell gives virgin B cells BAFF cytokine on their surface, prolonging their lifespan.
Follicular dendritic cells
Where in the lymph nodes do follicular dendritic cells (and B cells for a short while) live
Where in the lymph node do t cells live
What is converted to a T helper cell by the presentation of antigen on a tissue dendritic cell?
CD4 T cell
Where in the lymph node is the germinal centre of the follicle where activated B cells undergo affinity maturation and class switching of Igs
In the germinal centre B cells become one of 2 types of cell: what are they
(apical light zone) Memory B cells, - stick around in circulation until next time same pathogen arrives.
(basal light zone) Plasma cells - clone antibody factories
Where is Thrombopoeitin and Granulocyte colony stimulating factor (GCSF) produced (TPO) what do they do
TPO - create megakaryocyte -- then platelets
GCSF - creat neutrophils & eosinophils
Where is Erythropoietin produced (EPO) what does it do
Turns myeloid progenitor cell into RBC
3 Cytokines produced by macrophage in inflammatory response - cause vasodilation, attract neutrophils, incr endoth permeability
in thymus - First part of t cell maturation - cortical Thymic Epithelial Cells (cTEC) present MHC to T cells, if bind to it will survive
Second part of T cell maturation in Thymus - dendritic cell / medullary thymic epith cell (mTEC) presents self antigen - if T cell recognises = destroyed