Innate & Acquired Imm System Flashcards Preview

Immunology 9.14 > Innate & Acquired Imm System > Flashcards

Flashcards in Innate & Acquired Imm System Deck (26):
1

Are B & T cells from Lymphoid or Myeloid precursors?

Lymphoid

2

What is the most abundant class of antibody 75%

IgG

3

What is the first antibody to be made

IgM

4

Summarise what a B cells function is

Presents antibody immunoglobulin on cell surface - if antigen (eg on bacteria virus) matches it, the B cell will proliferate, making clones = antibody factories.
These antibodies attach to the bact antigen & "flag" it for destruction by macrophages.

5

Where are class 1 Major Histocompatibility Complexes (MHC) found & what do they do?

Surface of human cells, - "flag" to Killer T Cells that they are infected - killer T cell causes cell apoptosis.

6

Where are class 2 Major Histocompatibility Complexes (MHC) found & what do they do?

Outside of macrophages - present pathogen antigen to Helper T cells which create cytokines - furthering immune response.

7

The process of ensuring immature B cells do not recognise "self" which involves either Receptor editing or Anergy and occurs in bone marrow is what

Central tolerance

8

What is anergy

B cell is only mildly self recognising so is down graded and becomes unresponsive.

9

What is receptor editing

B cell antibodies that recognise self either change to new ones or apoptosis.

10

Process of continuing to ensure B cells do not recog self and occurs in 2ary lymph tissue is what

Peripheral tolerance

11

This immunoglobulin is the first to be created on virgin B cells

IgM

12

This immunoglobulin binds to invaders and opsonizes for phagocytes - most common Ig

IgG

13

This immunoglobulin found at mucosal surfaces and breast milk

IgA

14

This immunoglobulin prod in response to specific allergens and cause mast cells to degranulate

IgE

15

What type of cell gives virgin B cells BAFF cytokine on their surface, prolonging their lifespan.

Follicular dendritic cells

16

Where in the lymph nodes do follicular dendritic cells (and B cells for a short while) live

Cortex

17

Where in the lymph node do t cells live

Paracortex

18

What is converted to a T helper cell by the presentation of antigen on a tissue dendritic cell?

CD4 T cell

19

Where in the lymph node is the germinal centre of the follicle where activated B cells undergo affinity maturation and class switching of Igs

Cortex

20

In the germinal centre B cells become one of 2 types of cell: what are they

(apical light zone) Memory B cells, - stick around in circulation until next time same pathogen arrives.
(basal light zone) Plasma cells - clone antibody factories

21

Where is Thrombopoeitin and Granulocyte colony stimulating factor (GCSF) produced (TPO) what do they do

Bone marrow
TPO - create megakaryocyte -- then platelets
GCSF - creat neutrophils & eosinophils

22

Where is Erythropoietin produced (EPO) what does it do

Kidney
Turns myeloid progenitor cell into RBC

23

3 Cytokines produced by macrophage in inflammatory response - cause vasodilation, attract neutrophils, incr endoth permeability

TNF alpha
IL1
IL6

24

in thymus - First part of t cell maturation - cortical Thymic Epithelial Cells (cTEC) present MHC to T cells, if bind to it will survive

Positive selection

25

Second part of T cell maturation in Thymus - dendritic cell / medullary thymic epith cell (mTEC) presents self antigen - if T cell recognises = destroyed

Negative selection

26

Child presents with wide set eyes, low ears & cleft palate.
Has had multiple viral and fungal infections.
Congenital cardiac complications also.
Condition, how is it inherited, what is it called, what chromosome?

Digeorge syndrome
Autosomal dom.
Chroms 22 partial deletion
No thymus- so no T cells - hence viral infections.