Innate immunity: the immediate response to infection Flashcards Preview

Immunology > Innate immunity: the immediate response to infection > Flashcards

Flashcards in Innate immunity: the immediate response to infection Deck (13)
Loading flashcards...
1
Q

Immediate response components

A

Complement, cytokines, anti-microbial peptides.

2
Q

Most important component of complement

A

C3b, get’s attached to particles, opsonizing them

3
Q

C3a

A

Chemotactic, recruits other immune cells

4
Q

How are C3b attached?

A

Covalently

5
Q

Spontanous activation of C3

A

C3 sponatanously becomes iC3, get’s attached to B, that gets cleaved by D, creating iC3Bb. iC3Bb is a C3bBb convertase

6
Q

Alternative pathway amiplification

A

Fixed C3b cleaves and activates more C3, producing more C3b and C3a

7
Q

MAC attack

A

C3b2Bb cleaves C5, causing subsequent activation of C6, 7, 8 and 9. Forming membrane pore.

8
Q

Anaphylatoxin

A

C3a and C5a increases vascular permeability and recruits immune cells.

9
Q

Decay acceleration factor

A

Binds C3bBb and causes dissociation of Bb. Important for self-tolerance.

10
Q

Lectin pathway

A

Lectin (MBL) bound MASP-1 and 2 binds to mannose on bacteria. MASPs can cleave C4 to C4b, allowing association with C2a. C4b2a is is a C3bBb convertase.

11
Q

Classical pathway

A

C1 complex binds IgM or CRP. C1 generates C4b2a, generating C3bBb.

12
Q

Therapeutic targeting of C5

A

Can treat paroxysmal nocturnal hemoglobinurea

13
Q

Defensins

A

Const. secreted antimicrobials. Secreteds as pro-defensin. Defensin inserts itself in the membrane, causing pore formation.