insulinoma SDL

Question 1

does an increase in insulin raise or lower blood concentration of glucose

Answer 1

lower

Question 2

does an increase in insulin raise or lower blood concentration of amino acids

Answer 2

decrease

Question 3

does an increase in insulin raise or lower blood concentration of fatty acids

Answer 3

decrease

Question 4

does an increase in insulin raise or lower blood concentration of triglycerides

Answer 4

decrease

Question 5

complete table

Answer 5

Question 6

what are the tumours of the beta cells of the islets of langerhans called

Answer 6

insulinomas

Question 7

what do insulinomas do

Answer 7

produce excessive amounts of insulin resulting in hypoglycaemia

Question 8

what are 5 CNS signs of hypoglycaema

Answer 8

• lethargy
• incoordination
• unusual behaviour/mentation
• blindness
• unconciousness

Question 9

what are 3 msk signs of hypoglycaemia

Answer 9

• weakness
• muscle twitches
• convulsions
• trembling

Question 10

how do you diagnose an insulinoma

Answer 10

insulin to glucose ratio (low glucose to normal or high insulin), diagnostic imaging (CT) and biopsy
- demonstration of hypoglycaemia not enough as can be caused by other things
- insulin might not always be above ref range

Question 11

which counter regulatory hormone does prednisolone most closely resemble and how does it lead to an increase in blood glucose

Answer 11

corticosteroid (specifically cortisol)
corticosteroids decrease insulin resistance and therefore promote glucose production in the liver leading to an increase in blood glucose