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Flashcards in Integration of Metabolism Deck (28):
1

What organ can carry out all metabolic reactions in major pathways?

The liver

2

As a junction point, what can Glucose-6-P be converted to? (3) As a junction point, what can pyruvate be converted to? (4) As a junction point, what can acetyl-CoA be converted to? (3) (Hint CO2 is one)

  • Glycogen Pyruvate Ribose-5-P
  • Acetyl-Co-A Lactate Alanine OAA
  • CO2, Ketone bodies, Fatty Acids

3

What are the macromolecule units that feed into Acetyl CoA for Proteins, Carbohydrates, and Fats? What system does Acetyl CoA enter from there to create ATP and CO2?

Amino Acids, Monosacharides, Glycerol/FAs TCA Cycle

4

What is the preferred energy source of the following cel types? RBC, Brain, Adipose, Liver, Muscles

RBC: Glucose Brain: Glucose and Ketone bodies Adipose: Glucose, Fatty Acids Liver: Fatty Acids primarily depends on Muscles: Glucose, FAs, AAs

5

Name a few of the metabolic purposes of the Liver (this one not too important)

Processes incoming nutrients, responds to dietary conditions, maintains nutrient concentrations in blood, makes/secretes proteins, processes toxins and wastes

6

To what organ do AAs go after absorption and through what tube? What are some of the things the organ does with them? (3)

The liver through the hepatic portal vein Make proteins and other N molecules, gluconeogenesis, fuel

7

What does Adipose tissue synthesize and store? What does it release these as and in what system?

Synthesizes/Stores Triglycerides Releases FA's into the blood (go to muscle, heart, liver)

8

What energy reserves does the brain have? What does it depend on? What percent of the bodies O2 does it use? What energy source does it switch too after days of low glucose?

No energy reserves Glucose 20% Ketone bodies in TCA

9

How much glycogen storage does the heart have? What condition is tissue death from lack of O2 in the heart?

No glycogen stores Myocardial infarction

10

What percent of the bodys glycogen stores does skeletal muscle have? What is it missing to be able to export glucose?

75% Glucose 6 Phosphatase

11

In exercise, in what order do the following occur? Anaerobic Glycolysis Oxidative Phosphorylation ATP-PCr

Atp/PCr (fastest) ---> Anaerobic glycolysis ----> Oxidative System This is also the order of increasing total energy production

12

What is the Phosphagen system? Explain it a little

Regeneration of ATP by Phosphocreatine For stuff like sprinting, quickly uses its ATP stores, quickly replenished by phosphocreatine (PCr to ATP and Creatine)

13

What are the starting and ending carbon molecules in Anaerobic glycolysis? What is the effect on the muscles Is this sustainable? If not, what does it switch to?

Glucose/Glycogen to Lactate Provides energy but causes muscle fatigue Not sustainable, have to go to Ox-Phos

14

What is the Cori Cycle? What organs does it involve?

Regenerate glucose from lactate Muscle sends lactate to Liver to convert to glucose

15

In oxidative phosphorylation, How many ATP will NADH give you? FADH2?

2.5 1.5

16

What ratio is the Energy charge of the cell? What ratio is the reducing power of the cell? How do these ratios relate to each other?

Ratio of ATP to ADP NADH to NAD+ They are inverse

17

What type of molecule is Ghrelin, what organ secretes it, where does it act and what effect does it produce?

Peptide secreted by the stomach, acts in hypothalamus to stimulate appetite.

18

What are Satiety signals? Where are they released from/act on? What is the main one and what kind of molecule is it? What kind is its receptor and where is it located?

Signals of Feeling full/help digestion The gut-the brain Cholecystokinin (CCK) Peptide hormone G-Protein Coupled receptor, peripheral neurons

19

In terms of energy homeostasis levels over the course of hours or days, what are the reporting hormones and what do they report on?

Leptin: Status of triacylglycerol stores from adipocytes Insulin: Status of blood glucose from B cells of pancreas

20

In the fed state, what processes occur in the liver? (3)

Glycolysis Glycogen Synthesis Triacylglycerol synthesis

21

In the fasting state, what 4 processes occur in the liver? (4)

Glycogenolysis Gluconeogenesis Beta Oxidation Ketone body formation

22

In the fed state, in what form do Carbs, Fat, and proteins cross the intestine?

Glucose, Chylomicrons, Amino Acids

23

In the fasting state, what are the relative amounts of glucose, insulin, and glucagon?

Glucose low, insulin low, glucagon high

24

In the starvation state, what special molecule is created by the liver and where does it go?

Ketone bodies, Brain

25

How does insulin affect the following processes/molecules? Glucose Glycogen Glycolysis FAs

Glucose uptake, glycogen synthesis, increased glycolysis, fatty acid synthesis

26

How does Glucagon ffect the following processes/molecules? Glycogen Gluconeogeneis Fatty acids Ketones

Glycogenolysis Gluconeogenesis Fatty acid mobilization (use) Ketogenesis

27

What is Epinephrine (fight or flight) effects on the following? Heart rate Bp Respiratory passage size Glycogen Glucose

Increased HR, Bp, respiratory passage size Gycogenolysis Glycolysis

28

What does AMPK stand for and what is it's role? When ATP is high, what is AMPK activity? When ATP is low, what is effect on AMPK and what will it do? What does AMPK do enzymatically? What is the physical relationship between ATP and AMP in relation to AMPK?

  • AMP-activated protein Kinase, the cellular energy sensor
  • Inactive
  • Allosterically activated (gonna go turn off resource hoarders, turn on energy mobilizers
  • Phosphorylates many targets controlling energy
  • They compete for binding to AMPK allosteric sites