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Flashcards in INTEGRATIVE Deck (11):
1

Drugs which inhibit ____________
- colchicine
- griseofulvin
- azole antihelminthics (albendazole, etc)
- vinca alkaloids (vincristine, etc)
- paclitaxel, docetaxel

microtubule synthesis

2

Sumatriptan - 5HT1D receptor agonist
Ondansetron - ________
Ergotamine - 5HT2 receptor antagonist (______selective)
Ergonavine - 5HT2 receptor antagonist (______selective)

Sumatriptan - 5HT1D receptor agonist
Ondansetron - 5HT3 antsgonist
Ergotamine - 5HT2 receptor antagonist (vasoselective)
Ergonavine - 5HT2 receptor antagonist (uteroselective)

3

Alcohol withdrawal syndrome
Treatment
- correct electrolyte imbalance
- administer ___________
- Substituting a long-acting sedative-hypnotic drug for alcohol then gradually tapering the dose of the long-acting drug
- DOC is a ___________________ (e.g. Diazepam, chlordiazepoxide)
- Short-acting benzodiazepine with less complex metabolism (e.g. Lorazepam ) is preferred in patients with compromised liver function.

Alcohol withdrawal syndrome
Treatment
- administer thiamine
- Substituting a long-acting sedative-hypnotic drug for alcohol then gradually tapering the dose of the long-acting drug
- DOC is a long-acting benzodiazepine (e.g. Diazepam, chlordiazepoxide)
- Short-acting benzodiazepine with les complex metabolism (e.g. Lorazepam ) is preferred in patients with compromised liver function)

4

Delirium Tremens
HAD 48 mnemonic?

Hallucinations
Autonomic instability
Delirium
48-72 hours post-discontinuation

5

TREATMENT OF ALCOHOLISM
_______________ (opioid receptor antagonist) - decrease CNS effects of endogenous opioid peptides
_______________ (NMDA receptor antagonist)
_______________ - inhibits aldehyde dehydrogenase -> acetaldehyde accumulation leads to nausea, headache, flushing, and hypotension

TREATMENT OF ALCOHOLISM
Naltrexone (opioid receptor antagonist) - decrease CNS effects of endogenous opioid peptides
Acamprosate (NMDA receptor antagonist)
Disulfiram - inhibits aldehyde dehydrogenase -> acetaldehyde accumulation leads to nausea, headache, flushing, and hypotension

6

What drugs can cause disulfiram reaction? (6)

Chlorpropamide
CefoPerazone
CefoMandole
CefoTetan
Procarbazine
Metronidazole

(THINK: Clara took the Pre-Medical Test in the PM)

7

Methanol poisoning
- visual dysfunction, etc
- treatment:
--- ________ - retards formation of __________, acts as preferred substrate for alcohol dehydrogenase, competitively inhibits the oxidation of methanol
--- ________ - inhibitor of alcohol dehydrogenase

Methanol poisoning
- visual dysfunction, etc
- treatment:
--- ethanol - retards formation of formaldehyde, acts as preferred substrate for alcohol dehydrogenase, competitively inhibits the oxidation of methanol
--- fomepizole - inhibitor of alcohol dehydrogenase

8

Ethylene glycol poisoning
- severe acidosis and retinal damage due to accumulation of __________
- treatment: ethanol, fomepizole

oxalic acid

9

What drugs can cause livedo reticularis? (5)

A(LIVing)MAN reads fHM and GQ
Amantadine
Hydroxyurea
Minocycline
Gemcitabine
Quinidine

10

What drugs can cause erectile dysfunction? (8)

A SORE PeniS can't Fuck Hard:
SSRIs
Opiates
Risperidone
Ethanol, estrogen
Propranolol
Spironolactone
Finasteride
HCTZ

11

What drugs cause priapism?

Tigas Penis Qo, AyaW Bumaba
Trazodone
Papaverine
Sildenafil
Quetiapine
Alprostadil
Warfarin
Bupropion

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