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Flashcards in Integument Deck (19):
0

Condition affecting S. basale

- epidermiolytic bullosa simplex

1

Condition effecting s. spinosum

- epidermiolytic hyperkeratatosis

2

Conditions affecting S. granulosum

Epidermiolytic palmaplantar keratoderma

3

Condition resulting Desmosomes defects

Striate plantopalmar keratoma

4

Conditions from cornified cell envelope defect

- transglutaminase (TGA- 1)
- Vohwinkel syndrome (loricrin)
- congenital ichthyosiform erythroderma (TGA-1)

5

Abnormal lipid metabolism affecting (CCE)

Sjogrens-Larsson syndrome

6

Desmoglein 1 and 3 defects

- pemphigus foliaceous D1
- pemphigus vulgaris D3

7

Exfoliation

- regulated proteolytic process
- killikrein related serine peptidases (pH dependent)
-

8

Excess MTIF

- causes over production (MTIF is sequestered in nucleus until activated by a-MSH + MCR1 -> cAMP -> CREB -> MTIF txn
- occurs in melanoma

9

Melanosome transport

- kinesin transports melanosome along Mtube to bind melanophilin, which complexes with myosin Va which walks up F actin to exocytosis melanosome

10

transglutaminase (TGA- 1)

- cornified cell envelope defect

11

- Vohwinkel syndrome (loricrin)

- cornified cell envelope defect

12

- congenital ichthyosiform erythroderma (TGA-1)

cornified cell envelope defect

13

Condition involving BPAG -> hemidesmosomes

Bulluos pemphigus

14

Keratins 5 + 14

Epidermolytic bullosa simplex

15

Keratins 1 + 10

Epidermolytic hyperkeratosis

16

Keratin 9

Epidermolytic plantopalmar keratoderma

17

Desmoplakin (Cadherin) disorder

- striate plantoplamar keratoderma

18

Defects in TGA-1 and loricrin

- Vohwinkel syndrome (loricrin), congenital icthyosiform erythroderma (TGA-1)