Integumentary and Immunological Systems Flashcards Preview

Biology > Integumentary and Immunological Systems > Flashcards

Flashcards in Integumentary and Immunological Systems Deck (31):
1

What does the integument consist of?

Skin, hair, nails, mucous secretions

2

What is the pH of the skin?

Acidic from sebaceous gland oil secretions

3

What are the layers of the skin?

Dermis and epidermis connected together by basement membrane

4

What is the dermis?

Blood supply to skin and specialized cells

5

What is the epidermis?

Kerationcytes which differentiate into corneocytes (protective, waterproof, routinely replaced)

6

What is difference between humoral and cell-mediated immunity?

-Humoral: antibodies
-Cell mediated: combat fungal and viral infections

7

What occurs during inflammatory?

-Activated WBC release histamines
-Blood vessels dilate and increase permeability
-Increase flow of WBC to infection

8

Describe components of lymphatic system.

-Lymph flows through lymphatic vessels from lymph node to lymph node
-In extravascular space of most tissues

9

Lymph nodes and spleen...

...are reservoirs of WBC and filters for lymph (remove antigen-presenting cells and foreign matter)

10

Granulocytes

-Phagocytize antigens and antigenic material
-Neutrophils, Eusinophils, Basophils

11

Neutrophils

-Most common
-First responders, attract WBC
-Elevated in inflammation

12

Eusinophils

-Less common
-Asthmatic and allergic responses
-Fight intercellular parasites

13

Basophils

-Related to mast cells and allergic response
-Release histamine
-Fight ectoparasites

14

Monocytes

-Can differentiate into macrophages or dendritic cells
-Long-lived immune cells

15

Macrophages

-Phagocytize dead cells and pathogens
-Present fragments of antigens

16

Dendritic cells

-More focused on antigen presenting vs macrophages
-In areas in contact with external environment
-Important link to adaptive IS

17

T lymphocytes

-Random rearrangement of gene sequences
-Vast majority undergo cell apoptosis (react too well or not at all)
-Develop in bone marrow --(travel in blood--> mature in thymus

18

MHC

-Presents antigen on surface of antigen presenting cell

19

Cytotoxic T cells

-CD8+ cells recognize/attack MHCI complexes
-Viruses/developing tumors

20

Helper T cells

-CD4+ recognize/respond to MHCII complexes
-Release cytokines to stimulate IS response

21

Natural Killer Cells

-Behave similarly to both Tc and Th cells but respond to antigens presented by other types of cells
-Destroy cells marked for destruction

22

Memory T cells

-Quicker, more targeted response if antigen reappears

23

Regulatory or suppressor T cells

-Tone down T cell response to self cells or following an infection

24

B lymphocytes

-Express immunoglobulins with high affinity for antigen expressed by the stimulating T lymphocyte

25

Antibodies

-Light chain and heavy chain with S-S bonds
-N (antigen binding sites) C (constant) V (variable)

26

Active immunity

-Occurs as result of immune response
-Exposure to pathogen/antigen/vaccine
-Develop cells specific to particular antigen --> wks/mnths to build up

27

Passive immunity

-Transfer antibodies from one individual to another
-Pregnancy/injections of gamma globulin
-Immunity lost when antibodies no longer circulate

28

Transplant rejection

-Rejection of organ due to antigens on donated organ

29

Plasma cells

-Specialized B cells that produce antibodies

30

MHCI proteins

-Found on all cells

31

MHCII proteins

-Found on macrophages, B cells, T cells