Flashcards in Integumentary and Immunological Systems Deck (31):
What does the integument consist of?
Skin, hair, nails, mucous secretions
What is the pH of the skin?
Acidic from sebaceous gland oil secretions
What are the layers of the skin?
Dermis and epidermis connected together by basement membrane
What is the dermis?
Blood supply to skin and specialized cells
What is the epidermis?
Kerationcytes which differentiate into corneocytes (protective, waterproof, routinely replaced)
What is difference between humoral and cell-mediated immunity?
-Cell mediated: combat fungal and viral infections
What occurs during inflammatory?
-Activated WBC release histamines
-Blood vessels dilate and increase permeability
-Increase flow of WBC to infection
Describe components of lymphatic system.
-Lymph flows through lymphatic vessels from lymph node to lymph node
-In extravascular space of most tissues
Lymph nodes and spleen...
...are reservoirs of WBC and filters for lymph (remove antigen-presenting cells and foreign matter)
-Phagocytize antigens and antigenic material
-Neutrophils, Eusinophils, Basophils
-First responders, attract WBC
-Elevated in inflammation
-Asthmatic and allergic responses
-Fight intercellular parasites
-Related to mast cells and allergic response
-Can differentiate into macrophages or dendritic cells
-Long-lived immune cells
-Phagocytize dead cells and pathogens
-Present fragments of antigens
-More focused on antigen presenting vs macrophages
-In areas in contact with external environment
-Important link to adaptive IS
-Random rearrangement of gene sequences
-Vast majority undergo cell apoptosis (react too well or not at all)
-Develop in bone marrow --(travel in blood--> mature in thymus
-Presents antigen on surface of antigen presenting cell
Cytotoxic T cells
-CD8+ cells recognize/attack MHCI complexes
Helper T cells
-CD4+ recognize/respond to MHCII complexes
-Release cytokines to stimulate IS response
Natural Killer Cells
-Behave similarly to both Tc and Th cells but respond to antigens presented by other types of cells
-Destroy cells marked for destruction
Memory T cells
-Quicker, more targeted response if antigen reappears
Regulatory or suppressor T cells
-Tone down T cell response to self cells or following an infection
-Express immunoglobulins with high affinity for antigen expressed by the stimulating T lymphocyte
-Light chain and heavy chain with S-S bonds
-N (antigen binding sites) C (constant) V (variable)
-Occurs as result of immune response
-Exposure to pathogen/antigen/vaccine
-Develop cells specific to particular antigen --> wks/mnths to build up
-Transfer antibodies from one individual to another
-Pregnancy/injections of gamma globulin
-Immunity lost when antibodies no longer circulate
-Rejection of organ due to antigens on donated organ
-Specialized B cells that produce antibodies
-Found on all cells