Flashcards in Interactions between cells and their environments: Part 2 Deck (27):
Basal lamina underlies all ______
ECM is secreted by cells in the _____
What three things does the basil lamina surround?
2. fat cells
3. schwann cells
In the kidney, the basal lamina divides two ____ ____ and acts as a selective _____
What organizes the basal lamina?
What are three components of laminin?
What does laminin bind to? (2)
2. other components of ECM including other laminin molecules
Type IV collagen provides strength and forms a...
strong, flexible felt-like network
What kind of common interactions are there between the different components of the basal lamina and ECM?
True of false: the "heads" of the type IV collagen interact with each other
The basal lamina is an attachment site for what kind of cells?
The basal lamina prevents _______ in the underlying _____ _____ from interacting with epithelial cells.
The basal lamina allows passage of ______ and ______
macrophages and lymphocytes
Is the ECM a static structure?
no, remodeled over time (e.g. bones change)
What is the ECM composed of?
connective tissues such as bones and tendons
What are the two types of components in the ECM?
1. protein components (laminin, type IV collagen,...)
2. glycoaminoglycans (GAGs)
What are GAGs? What do they form?
-long, linear, polysaccharide chains composed of a repeating disaccharide
-form a voluminous hydrated gel
GAGs are pairs of _____
sugars; one is an amino sugar
What kind of charge do GAGs have?
highly negative charge (attract Na+ and water)
What is hyaluronan?
a simple GAG not linked to a protein; it is spun directly from the cell surface by a membrane protein complex
Where and how are most GAGs synthesized?
inside the cell on proteins by exocytosis
What is the difference between proteoglycans and glycoproteins?
proteoglycans: a protein with at least one sugar side chain that is a GAG
glycoproteins: a protein with any sugar side chain
True or false: All glycoproteins are proteoglycans
What is elastin?
an elastic fibre that stretches and relaxes like a rubber band
Cadherins form _____ junctions
What is a plant cell wall composed of?
cellulose and pectin