Interactions between cells and their environments: Part 2 Flashcards Preview

Biology > Interactions between cells and their environments: Part 2 > Flashcards

Flashcards in Interactions between cells and their environments: Part 2 Deck (27):
1

Basal lamina underlies all ______

epithelia

2

ECM is secreted by cells in the _____

tissue

3

What three things does the basil lamina surround?

1. muscle
2. fat cells
3. schwann cells

4

In the kidney, the basal lamina divides two ____ ____ and acts as a selective _____

cell sheets
filter

5

What organizes the basal lamina?

laminin

6

What are three components of laminin?

alpha-laminin
beta-laminin
gamma-laminin

7

What does laminin bind to? (2)

1. integrin
2. other components of ECM including other laminin molecules

8

Type IV collagen provides strength and forms a...

strong, flexible felt-like network

9

What kind of common interactions are there between the different components of the basal lamina and ECM?

protein-protein interactions

10

True of false: the "heads" of the type IV collagen interact with each other

false

11

The basal lamina is an attachment site for what kind of cells?

epithelial cells

12

The basal lamina prevents _______ in the underlying _____ _____ from interacting with epithelial cells.

fibroblasts
connective tissue

13

The basal lamina allows passage of ______ and ______

macrophages and lymphocytes

14

Is the ECM a static structure?

no, remodeled over time (e.g. bones change)

15

What is the ECM composed of?

connective tissues such as bones and tendons

16

What are the two types of components in the ECM?

1. protein components (laminin, type IV collagen,...)
2. glycoaminoglycans (GAGs)

17

What are GAGs? What do they form?

-long, linear, polysaccharide chains composed of a repeating disaccharide
-form a voluminous hydrated gel

18

GAGs are pairs of _____

sugars; one is an amino sugar

19

What kind of charge do GAGs have?

highly negative charge (attract Na+ and water)

20

What is hyaluronan?

a simple GAG not linked to a protein; it is spun directly from the cell surface by a membrane protein complex

21

Where and how are most GAGs synthesized?

inside the cell on proteins by exocytosis

22

What is the difference between proteoglycans and glycoproteins?

proteoglycans: a protein with at least one sugar side chain that is a GAG
glycoproteins: a protein with any sugar side chain

23

True or false: All glycoproteins are proteoglycans

false

24

What is elastin?

an elastic fibre that stretches and relaxes like a rubber band

25

Cadherins form _____ junctions

homotypic

26

What is a plant cell wall composed of?

cellulose and pectin

27

What is plasmodesmata?

junctions between cell walls