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B2: microbiology > Interferon :part 1 > Flashcards

Flashcards in Interferon :part 1 Deck (20)
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1

What is the most common cause of sporadic encephalitis worldwide?

Herpes simplex encephalitis

2

Which subset of the population is herpes encephalitis most common in?

Most common in childhood – affecting previously healthy individuals on primary infection with HSV-1

3

What is interferon?

Transferrable factor produced when the cells are exposed to virus

4

What is the effect of interferon binding to interferon receptors on cells?

It binds to specific receptors and signals the de novo transcription of hundreds of interferon stimulated genes (ISG), these genes are what make you feel ill and carry out processes in the body to get rid of the virus. 

5

What are the three functions of type I interferons?

Induce ISGs in infected and neighboring cells

Increase antigen presentation and chemokine prodcution in innate cells

Increase antibody production

Increase effector T cell response

6

What are the type I interferons?

IFN alpha and IFN beta

7

What is the first interferon to be produced in a viral infection?

IFN beta

8

Which cells produce IFN beta?

All cells produce IFN beta and all tissues have IFNAR receptors

9

What is IFN beta induction triggered by?

IRF-3

10

Name a cell type that is specialised for producing IFN alpha.

Plasmacytoid dendritic cells

11

What do cells specialised for producing IFN alpha.express high levels of?

IRF-7

12

How many genes are there for IFN alpha and IFN beta?

Alpha – 13/14 isotypes Beta – ONE

13

Which IFN comes under type II interferon?

IFN-gamma - specialist immune signalling molecule

14

Which cell types produce IFN-gamma?

Produced by activated T cells and NK cells

15

Which receptor does IFN-gamma signal through?

IFNGR

16

Which IFN falls under type III IFN?

IFN-lambda

17

Which receptors do type III IFNs signal through?

IL-28 receptors IL-10 beta receptors

18

Where are  type III IFN receptors mainly present?

Epithelial surfaces E.g. respiratory epithelium and gut

19

•Polymorphisms in IFN lambda associated with improved outcome from HCV and HBV both spontaneous clearance and response to antiviral therapy T/F

T

20

List the different types of PRRs

TLR,RLR and cGAS(DNA sensor)