Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MEH > Interpreting FBC > Flashcards

Interpreting FBC Flashcards

1
Q

Causes of increased mean cell volume (MCV)?

A

Megaloblastic anaemia (B12, folate)
Liver disease
Alcohol, smoking
Haemolytic anaemia
Hypothyroidism
Drugs
Myelodysplasia
Myeloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Causes of decreased mean cell volume (MCV)?

A

Iron deficiency anaemia
Thalassaemia
Anaemia of chronic disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Red cell distribution width (RDW)

A

The variation in the size of the RBC

-> increased RDW = increased variation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Anisocytosis

A

Increased variation in size of RBC (increased RDW)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How can RDW be used?

A

Asses the cause or timeline of anaemia
Eg RDW increased in developing or recently treated iron deficiency
RDW increased is normal is thalassaemia trait
RDW increased during haemolysis due to presence of reticulocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Mean cell haemoglobin (MCH)

A

Average measure of the amount of Hb in each RBC.

Used in assessment of anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Why would MCH be: reduced? Raised? Normal?

A

Reduced - iron deficiency, thalassaemia, haemoglobinopathy
Raised - macrocytic anaemias
Normal - mixed deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Reticulocyte count

A

Measurement of number of young erythrocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Reasons for increased reticulocyte count?

A

Haemolytic anaemia
Recent blood loss
Response to iron, vit B12, folate replacement
Response to EPO
Recovery from bone marrow suppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Reasons for decreased reticulocyte count?

A

Haematinic deficiency
Bone marrow failure
Parvovirus infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Dimorphism

A

Two distinct populations of RBC (post transfusion)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Polychromatic

A

Two different stainings in blood film - reticulocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Poikilocytosis

A

Abnormally shaped RBC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Spherocytosis

A

Spherical RBC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Elliptocytosis

A

Elliptical RBC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Irregularly contracted calls

A

Small dense RBC but not as regular in shape as spherocytes

17
Q

Echinocytes

A

Spiculated cells

18
Q

Acanthocytes

A

Spiculated cells

19
Q

Keratocytes

A

Spiculated cells

20
Q

Schistocytes

A

Red cell fragments

21
Q

Sickle cells

A

Crescent or sickle shaped cells seen in sickle cell disease

22
Q

Target cells

A

RBC with dark area in middle of the area of central pallor

23
Q

Blister cells

A

Empty pocket at the edge of the red cell, consistent with oxidative haemolysis/G6PDH deficiency

24
Q

Howell Jolly bodies

A

DNA/nuclear fragments

25
Q

Basophilic stippling

A

RNA inclusions

26
Q

Pappenheimer bodies

A

Iron inclusions (Perl’s stain)

27
Q

Heinz bodies

A

Denatured Hb (aggregates)

28
Q

Haemoglobin H inclusions

A

“Golf-ball cells” - beta chain tetramers found in severe alpha thalassaemia

(Brilliant cresyl blue) - ?

29
Q

What abnormality may be present in the blood film of a patient with G6PDH deficiency? (There are two)

A

Blister cells
Heinz bodies

30
Q

Pencil cells

A

Pencil shaped cells (elliptocytes)

31
Q

What expected results would you get from iron deficiency?

A

Decreased Hb, MCV, MCH, MCHC
Increased RDW
Low or normal reticulocyte count
Cells present in blood include hypochromic, microcytic, pencil cells, a few target cells

32
Q

What expected results would you get from vit B12/folate deficiency?

A

Decreased HB, RCC, Hct (haematocrit)
Increased RDW, MCH, MCV
Low or normal reticulocyte count
Cells present in blood include oval macrocytes, hypersegmented neutrophils, teardrop cells

33
Q

Causes of macrocytosis

A

Alcohol/smoking
Drugs interfering with DNA synthesis (methotrexate)
Bone marrow failure conditions

34
Q

What expected results would you get from haemolysis?

A

Decreased or normal Hb
Increased or normal MCV
Increased RDW
Normal MCH
Elevated reticulocyte count
Cells present in blood include spherocytes, schistocytes, polychromasia

MEH (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions