Interstitial Lung Disease 2 - Pathology Flashcards Preview

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Flashcards in Interstitial Lung Disease 2 - Pathology Deck (12):
0

What does "interstitium" really refer to..?

Alveolated lung parenchyma

1

4 different histological patterns of interstitial lung disease?

Chronic inflammation.
Type II pneumocyte hyperplasia.
Granulomas
Fibrosis.

2

"Organizing fibrosis" - is it reversible?

Yes, potentially.
Moreso than honeycomb fibrosis etc.

3

3 things (listed in this lecture) that can cause UIP other than IPF?

Asbestosis.
Radiation exposure.
Connective tissue disease.

4

Histological features of UIP?

Dense collagen.
Minimal chronic inflammation.
Scattered fibroblastic foci.

5

What do the affected lymph nodes of a patient with sarcoidosis look like in histology?

Many confluent non-necrotizing granulomas.

6

What does hypersensitivity pneumonitis look like in histology?

Small airway histology.
Diffuse chronic interstitial inflammation.

7

Common allergens in hypersensitivity pneumonitis?

Mold.
Bird poop.

8

Should you consider drug-mediated injury as a possible cause of interstitial lung disease?

yup.

9

What behavior enhances the deleterious effects of dust exposure?

Smoking - the cilia won't work as well to clear the crap.

10

What is a ferruginous body?
What do they indicate?

An asbestos fiber that macrophages have coated with iron and glyoprotein.
These indicate asbestos exposure - not asbestosis.

11

What is asbestosis? (what is it not?)

Asbestosis is severe peribronchiolar and then interstitial fibrosis, most severe in the lower lobes - with ferruginous/asbestos bodies.
(It's not calcified pleural plaques, it's not asbestos-associated cancer.)