Intra-abdominal infection and gastroenteritis Flashcards Preview

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Flashcards in Intra-abdominal infection and gastroenteritis Deck (28):
1

Blood tests for intra-abdo infection

FBC- neutrophilia/neutropenia
CRP raised
LFTs abnormal in hepatobiliary disease

2

Imaging in intra-abdo infection

CXR- consolidation, effusion, low lobe pneumonia can present as abdo pain
USS- masses, free fluid, dilated bile ducts
CT

3

Rx of abscess

Drainage

4

Antibiotics for source other than intestinal?

Depends on source

5

Flora of GI tract that might cause intra-abdo infection

E. coli
Pseudomonas
Bacteroides
Prevotella
Enterococcus
Clostridium

6

Are there more obligate anaerobic bacteria or facultative anaerobes in the colon?

Obligate

7

List the pathongens that cause gastroenteritis

Bacillus cereus
Vibrio cholerae
Salmonella
Campylobacter
Shigella
E coli
Staph aureus
Enteamoeba hist.
Giardia lamblia
Cryptosporidium
Norovirus
Rotavirus
(and can also get non-infective)

8

Complications of gastroenteritis

Dehydration
Renal failure
Haemolytic uraemic syndrome
Toxic megacolon
Guillain-Barre Syndrome
Salmonella

9

What tests would you do on a stool sample for gastroenteritis

OCP- ova, cysts, parasites
MC&S- microscopy, culture and sensitivity
C. diff toxin

10

How is cryptosporidium gastroenteritis spread?

waterborne (oocytes resistant to chlorine based disinfectants)

11

Which bacterial causes of gastroenteritis produce enterotoxins?

Bacillus cereus
Vibrio cholerae
C diff
C perfrigens
Staph aureus
Ecoli

12

Which bacterial causes of gastroenteritis have a mechanism of adherence to cells?

Shigella
E. coli
Campylobacter jejuni
Salmonella

13

What is the affect of the E. Coli strain EHEC/VTEC

Enterohaemorrhagic
Colitis/HUS

14

What is the affect of the E. Coli strain ETEC

Enterotoxigenic
Traveller's diarrhoea

15

What is the affect of the E. Coli strain EAggEC

Enteroaggregative
Traveller's diarrhoea

16

What is the affect of the E. Coli strain EIEC

Enteroinvasive dysentry like

17

What is the affect of the E. Coli strain EPEC

Enteropathogenic
Childhood diarrhoea

18

E. Coli strain 0157 uses what virulence factor?

Shiga toxin virulence factor

19

Source of E coli 0157?

Cattle

20

Severe complication of 0157?

Haemolytic uraemic syndrome in 10-15% because acts on RBCs

21

Mechanism of 0157 toxin

Similar to cholera- g proteins activated, more cAMP, more ion channels activated, increased Cl efflux, water follows into the gut.

22

Why can killing the bacteria make e coli worse?

More toxins released

23

Does salmonella produce a toxin?

No

24

4 strains of salmonella

S. typhi
S. paratyphi
S. enteritidis
S. typhimurium

25

Typhoidal strains of salmonella......?

affect cells outside of the GI tract also

26

Treatment of gastroenteritis?

Supportive
Avoid Abx except:
-Very young/old
-Campylobacter
-Spread outside GI tract (+ve blood culture)

27

C. diff treatment

Metronidazole/vancomycin (oral)
Faecal transplant

28

Treatment for intraperitoneal infection of intestinal source

65yrs- piperacillin/tazobactam