Flashcards in Intro to Immunology Deck (33):
Atopic diseases are more commonly known as what?
What are the 4 main roles of the immune system?
1. Defense against infections
2. Defense against tumors
3. Inflammatory responses
4. Host v. non-host
What does CD stand for?
Cluster of differentiation
The messengers of the immune system are commonly known as _____________
The two main types of immunity?
Innate and adaptive
What are the subcategories of adaptive immunity?
Passive (artificial and natural)
Active (artificial and natural)
What is the fast immune response? Slow?
Innate immune system responds on the hours timeline while adaptive responds on the day timeline
Is adaptive immunity specific or non-specific?
Specific, it is the learning immunity
What is the default state of innate immunity?
It is turned off unless needed
Innate immune cells generally follow what lineage?
Myeloid stem cells
Eosinophils differentiate in response to ___________
Eosinophils make up ________ % of white blood cells
Eosinophils are short-lived, they usual live in circulation for ______________
What was the primary responsibility of eosinophils? What do they do now?
Multicellular parasites, atopic diseases
Basophils are non-_____________ and generally have ____________ nucleus
(T/F) basophils are granulated
What are basophils stained with?
What is one of the major compounds released by basophils?
Mast cells often live in ______________
What are the two types of mast cells?
Tissue and mucosal
Mast cells play a role in what 2 responses?
Inflammatory and atopic
Mast cells granules are made of:
Histamine, proteases, heparin, TNF
Mast cells serve to active more
What lineage do NK cells come from?
What are NK activated by?
IL12 (macrophages), IL15, Type I IFNs
Activated NK activate macrophages by ___________
NK function in the destruction of ______________ cells
Circulating monocytes are called _______________
Monocytes/macrophages function in quick or prolonged defense?
What type of cells function as professional APC?
Neutrophils are ______lived and respond __________
__________ immunity uses antibodies to neutralize and eradicate exogenous antigens