Intro to Immunology Flashcards Preview

HDM Midterm - Brett > Intro to Immunology > Flashcards

Flashcards in Intro to Immunology Deck (33):
1

Atopic diseases are more commonly known as what?

Allergies

2

What are the 4 main roles of the immune system?

1. Defense against infections
2. Defense against tumors
3. Inflammatory responses
4. Host v. non-host

3

What does CD stand for?

Cluster of differentiation

4

The messengers of the immune system are commonly known as _____________

Cytokines

5

The two main types of immunity?

Innate and adaptive

6

What are the subcategories of adaptive immunity?

Passive (artificial and natural)
Active (artificial and natural)

7

What is the fast immune response? Slow?

Innate immune system responds on the hours timeline while adaptive responds on the day timeline

8

Is adaptive immunity specific or non-specific?

Specific, it is the learning immunity

9

What is the default state of innate immunity?

It is turned off unless needed

10

Innate immune cells generally follow what lineage?

Myeloid stem cells

11

Eosinophils differentiate in response to ___________

IL5

12

Eosinophils make up ________ % of white blood cells

1-6

13

Eosinophils are short-lived, they usual live in circulation for ______________

8-12 hours

14

What was the primary responsibility of eosinophils? What do they do now?

Multicellular parasites, atopic diseases

15

Basophils are non-_____________ and generally have ____________ nucleus

Phagocytic, bi-lobed

16

(T/F) basophils are granulated

T

17

What are basophils stained with?

Methylene blue

18

What is one of the major compounds released by basophils?

Histamine

19

Mast cells often live in ______________

Tissues

20

What are the two types of mast cells?

Tissue and mucosal

21

Mast cells play a role in what 2 responses?

Inflammatory and atopic

22

Mast cells granules are made of:

Histamine, proteases, heparin, TNF

23

Mast cells serve to active more

WBCs

24

What lineage do NK cells come from?

Lymphoid

25

What are NK activated by?

IL12 (macrophages), IL15, Type I IFNs

26

Activated NK activate macrophages by ___________

IFN-gamma

27

NK function in the destruction of ______________ cells

Cancer

28

Circulating monocytes are called _______________

Macrophages

29

Monocytes/macrophages function in quick or prolonged defense?

Prolonged

30

What type of cells function as professional APC?

Dendritic cells

31

Neutrophils are ______lived and respond __________

Short, rapidly

32

__________ immunity uses antibodies to neutralize and eradicate exogenous antigens

Humoral

33

____________ immunity eradicates endogenous antigens

Cell-mediated