Iron preperations Flashcards
People with higher daily requirement of iron
Pregnant women
Infants
When is hypochromic microcytic anemia developed?
When iron stores have been significantly depleted.
Oral iron preparations - 3 drugs
Ferrous salts (ferrous sulfate, ferrous gluconate, ferrous fumarate).
Oral iron preparations - interactions
Food decrease uptake by 40-60%.
Bile acid-binding resins (cholestyramine) reduce absorption.
Ascorbic acid: increase absorption.
Iron reduces absorption of: tetracyclines, fluoroquinolones, levothyroxine, vitamin E.
Duration of treatment of uncomplicated iron deficiency anemia
4-6 months
Iron salts - adverse effects
Epigastric pain, nausea, vomiting, diarrhea, constipation, black stools.
Liquid iron: staining of the teeth.
High dose: lethal toxicity.
Parenteral iron preparations - 3 drugs
Iron dextran
Iron sucrose
Sodium ferric gluconate
What parenteral iron preparation has fewer adverse effects?
Low-molecular-weight preparation of iron dextran.
Iron dextran - adm and indications
IV or intramuscular
Pts who cannot tolerate/no response to oral therapy
Iron dextran - adverse effects according to administration.
IV: Peripheral flushing, hypotensive reactions.
IM: Pain, inflammation, sterile abscesses, brown discoloration at injection site.
Rarely causes anaphylactic shock.
Iron sucrose - indications
Anemia in chronic kidney disease.
