IV - Hemodynamic Disorders, Thrombosis and Shock Flashcards Preview

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Flashcards in IV - Hemodynamic Disorders, Thrombosis and Shock Deck (153)
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31

Receptors responsible for platelet adhesion.

GpIb receptors- platelet Von Willebrand factor - endothelium(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.88

32

Deficiency of GpIb receptors.

Bernard-Soulier syndrome(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.88

33

Deficiency of GpIIb-IIIa receptors.

Glanzmann thrombasthenia(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.88

34

It is a membrane-bound procoagulant glycoprotein synthesized by endothelium, which becomes exposed at the site of injury.

Thromboplastin/Factor III(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.88

35

Formation of a hemostatic plug due to platelet aggregation

Primary hemostasis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.86

36

Hemostasis characterized by activation of thrombin through the coagulation cascade.

Secondary hemostasis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.86

37

True or false:The primary aggregation of platelets is irreversible.

False.(TOPNOTCH)

38

Two substances essential for the formation of a primary hemostatic plug.

ADP and TXA2(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.87

39

True or false:Activation of the coagulation cascade and subsequent thrombin formation is reversible.

False. Irreversible(TOPNOTCH)

40

Substance that activates the coagulation proteins.

Calcium(TOPNOTCH)

41

Substance that mediates further platelet aggregation and degranulation.

ADP(TOPNOTCH)

42

Substance that increases platelet activation and causes vasoconstriction. Synthesized by activated platelets.

TXA2(TOPNOTCH)

43

Most important initiator of the coagulation cascade.

Tissue factor(TOPNOTCH)

44

A protein found on endothelial cells involved in the breakdown of blood clots which catalyzes conversion of plasminogen to plasmin.

Tissue plasminogen activator (t-PA) and Urokinase(TOPNOTCH)

45

Components of Virchow's triad?

Endothelial injuryStasisHypercoagulability(TOPNOTCH)

46

It is a major contributor to the development of VENOUS thrombi.

Stasis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.94

47

Type of blood flow found in normal blood vessels, wherein platelets flow centrally in the vessel lumen, separated from the endothelium by a slow moving clear zone of plasma.

Laminar flow(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.94

48

Alteration in blood flow that contributes to arterial and cardiac thrombosis by causing endothelial injury or dysfunction as well as formation of countercurrents and local pockets of stasis.

Turbulence(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.94

49

Any alteration of the coagulation pathway that predisposes to thrombosis.

Hypercoagulability(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.95

50

A detached, intravascular solid, liquid or gaseous mass that is carried by the blood distal to its point of origin.

Embolus(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.95

51

Apparent laminations seen in a thrombus, representing pale platelet and fibrin layers alternating with darker erythrocyte-rich layers.

Lines of Zahn(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.96

52

Significance of Lines of Zahn?

Represents thrombosis in the setting of blood flow, seen in antemortem clots.(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.96

53

Thrombi occuring in heart chambers or aortic lumen

Mural thrombi(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.96

54

Gelatinous thrombi with a dark red dependent portion where red cells have settled by gravity with a yellow "chicken fat" supernatant. Usually unattached to underlying wall.

Postmortem thrombi(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.96

55

Thrombi on heart valves.

Vegetations(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.96

56

Sterile, verrucous endocartidis occuring in patients with SLE.

Libman-Sacks endocartidis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.96

57

Vegetations occuring in the presence of non-infected valves in hypercoagulable states.

Nonbacterial thrombotic endocarditis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.96

58

Fate of a thrombus wherein the thrombus accumulates additional platelets and fibrin, eventually causing vessel obstruction.

Propagation(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.97

59

Fate of a thrombus wherein it may dislodge or fragment and transported elsewhere in the vasculature.

Embolization(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.97

60

Fate of a thrombus as a result of of fibrinolytic activity leading to rapid shrinkage and even total lysis of recent thrombi.

Dissolution(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.97