IV - Topnotch Pharma Flash Cards - CNS Drugs Preview

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Flashcards in IV - Topnotch Pharma Flash Cards - CNS Drugs Deck (156)
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1

bind GABA-A receptor subunits to increase frequency of chloride channel opening which causes membrane hyperpolarization

benzodiazepines (TOPNOTCH)

2

SE: anterograde amnesia, decreased psychomotor skills, unwanted daytime sedation, tolerance, dependence liability and rebound insomnia or anxiety

benzodiazepines (TOPNOTCH)

3

BZD that can be used for seizure disorders, Bipolar disorder and infantile spasm

Clonazepam (TOPNOTCH)

4

Why is Lorazepam preferred over Diazepam in status epilepticus

due to its long distribution halflife (TOPNOTCH)

5

date-rape drug

Flunitrazepam (TOPNOTCH)

6

BZD used for alcohol withdrawal

Diazepam and Chlordiazepoxide (TOPNOTCH)

7

antagonist at benzodiazepine sites on GABA-A receptor

Flumazenil (TOPNOTCH)

8

bind to GABA-A receptor sites to increase duration of chloride channel opening, block glutamic acid neurotransmission

barbiturates (TOPNOTCH)

9

which has greater dependence liability: barbiturates or benzodiazepine

barbiturates (TOPNOTCH)

10

Barbiturate with the highest lipid solubility

Thiopental (TOPNOTCH)

11

barbiturate for status epilepticus

Phenobarbital (TOPNOTCH)

12

SE: acute intermittent porphyria

barbiturates (TOPNOTCH)

13

High dose BZD and Barbs may suppress seizure but at the expenses of marked sedation EXCEPT for

Clonazepam and Phenobarbital (TOPNOTCH)

14

only interact with GABA-A receptors with alpha-1 subunit; For insomnia and sleep disorder esp when sleep onset is delayed

Zolpidem, Zaleplon, Eszopiclone (TOPNOTCH)

15

dependence liability and withdrawal symptoms is less than that of benzodiazepines

Zolpidem, Zaleplon, Eszopiclone (TOPNOTCH)

16

lack anti-convulsant, anti-anxiety and muscle relaxant effects, effects are reversed with Flumazenil, very rapid onset of action, may dec REM sleep

Zolpidem, Zaleplon, Eszopiclone (TOPNOTCH)

17

increasing use due to rapid onset with minimal effects on the sleep pattern and cause less daytime cognitive impairment as compared to BZD

Zolpidem, Zaleplon, Eszopiclone (TOPNOTCH)

18

partial agonist at 5-HT1A receptors and possibly D2 receptors, used For generalized anxiety disorders

Buspirone (TOPNOTCH)

19

slow onset of action (more than 1week), metabolized by CYP3A4, safe for pregnant patients

Buspirone (TOPNOTCH)

20

activates melatonin receptors (MT1 and MT2 receptors) in the suprachiasmatic nuclei in the CNS leading to dec latency of sleep onset

Ramelteon (TOPNOTCH)

21

block voltage-gated Na channel; DOC for generalized tonic-clonic seizures, DOC for partial seizures, can be used for migraine

Phenytoin, Fosyphenytoin, Mephenytoin, Ethotoin (TOPNOTCH)

22

SE: nystagmus, diplopia, sedation, gingival hyperplasia, hirsutism, anemias, peripheral neuropathy (absent DTRs), osteoporosis, fetal hydantoin syndrome, abnormalities in Vit D metabolism

Phenytoin, Fosyphenytoin, Mephenytoin, Ethotoin (TOPNOTCH)

23

preferred in prolonged therapy for status epilepticus because it is less sedating

phenytoin (TOPNOTCH)

24

block voltage-gated Na channels and decreases glutamate release; DOC for trigeminal neuralgia, DOC for generalized tonic-clonic seizures, DOC for partial seizures, for bipolar disorders

Carbamazepine, Oxcarbazepine (TOPNOTCH)

25

SE: diplopia, cognitive dysfunction, drowsiness, ataxia, blood dyscrasias, Stevens-Johnson syndrome, erythematous rash, teratogen (spina bifida and craniofacial anomalies), hyponatremia

Carbamazepine, Oxcarbazepine (hyponatremia) (TOPNOTCH)

26

may be used for acute manic phase and as prophylaxis in the depressive phase

Carbamazepine, Oxcarbazepine (TOPNOTCH)

27

blocks high-frequency firing of neurons which modifies amino acid metabolism; DOC for bipolar disorder (acute mania), DOC for generalized tonic-clonic seizures and absence seizure, partial seizures, myoclonic seizures, also used for Bipolar disorders

Valproic acid (TOPNOTCH)

28

anti-manic that is CYP450 inhibitor

Valproic acid (TOPNOTCH)

29

for status epilepticus in children ; primary anticonvulsant in infants, children and pregnant patients

Phenobarbital (TOPNOTCH)

30

inhibit low threshold (T-type) Ca currents esp in thalamic neurons ; DOC for absence seizure

Ethosuximide, Phensuximide, Methsuximide (TOPNOTCH)