Flashcards in Jaundice Deck (12):
when is jaundice usually visible?
what is pre-hepatic/haemolytic jaundice?
pathology is occurring prior to the liver due to either:
- intrinsic defects in RBC
- extrinsic causes external to RBC
results from saturation of the bilirubin conjugation process
bilirubin is UNCONJUGATED so does not appear in the urine
intestinal bacteria convert some of the extra bilirubin into urobilinogen -- reabsorbed by kidney -- increased urinary urobilinogen
causes of pre-hepatic jaundice
findings in pre-hepatic jaundice
what is hepatocellular jaundice?
pathology is located within the liver due to disease of parenchymal cells of liver
partial inability to conjugate bilirubin
leads to mixed conjugated and unconjugated bilirubin in the blood
severe: inability to conjugate therefore unconjugated hyperbilirubinaemia
causes of hepatocellular jaundice
causes of unconjugated hyperbilirubinaemia
causes of conjugated hyperbiliribinaemia
cholestasis of pregnancy
signs of hepatocellular jaundice
slightly pale stools
what is obstructive jaundice?
pathology is located after the conjugation of bilirubin in the liver caused due to obstruction of biliary passage
what are the signs of obstructive jaundice?