Jaundice Flashcards Preview

CLP - Hepato-Biliary > Jaundice > Flashcards

Flashcards in Jaundice Deck (12):
1

when is jaundice usually visible?

50umol/L

2

what is pre-hepatic/haemolytic jaundice?

pathology is occurring prior to the liver due to either:
- intrinsic defects in RBC
- extrinsic causes external to RBC
results from saturation of the bilirubin conjugation process
bilirubin is UNCONJUGATED so does not appear in the urine
intestinal bacteria convert some of the extra bilirubin into urobilinogen -- reabsorbed by kidney -- increased urinary urobilinogen

3

causes of pre-hepatic jaundice

sickle cell
malaria
thalmassemia

4

findings in pre-hepatic jaundice

normal stools
normal urine

5

what is hepatocellular jaundice?

pathology is located within the liver due to disease of parenchymal cells of liver
partial inability to conjugate bilirubin
leads to mixed conjugated and unconjugated bilirubin in the blood
severe: inability to conjugate therefore unconjugated hyperbilirubinaemia

6

causes of hepatocellular jaundice

Gilberts
viral hepatitis
malignancy

7

causes of unconjugated hyperbilirubinaemia

haemolysis
ineffective erythropoiesis
Gilberts
Crigier-Niajjar syndrome
thyroid disease

8

causes of conjugated hyperbiliribinaemia

cholestasis of pregnancy
alcohol abuse
viral infection
sepsis
PBC
PSC
pancreatic disease
drugs

9

signs of hepatocellular jaundice

dark urine
slightly pale stools

10

what is obstructive jaundice?

pathology is located after the conjugation of bilirubin in the liver caused due to obstruction of biliary passage

11

what are the signs of obstructive jaundice?

dark urine
pale stools
steatorrhoea

12

types of obstructive jaundice and their causes

intrahepatic - obstruction of hepatic bile canaliculi; failure of bile secretion - bilirubin is UNconjugated
-causes: hep, cirrhosis, neoplasm, drugs, pregnancy
extrahepatic - obstruction of hepatic ducts, or biliary tree, distal canaliculi - bilirubin is conjugated
- causes: gallstones, cholangiocarcinoma, PSC, congenital atresia of CBD, pancreatitis, tumour of pancreatic head