Jitt # 11 Acquired Immune Deficiency Disorder Flashcards Preview

Medical Immunology Bios 443/843 > Jitt # 11 Acquired Immune Deficiency Disorder > Flashcards

Flashcards in Jitt # 11 Acquired Immune Deficiency Disorder Deck (6):
1

What type of cell does HIV infect? How does it do this?

HIV infects CD4 cells. The CD4 receptor is the receptor for HIV. CD4 is also a receptor on macrophages, and is susceptible to infection gp120 on the surface of HIV binds CD4. (megakaryocytes; glial cells; may also be infected)

2

What are the co-receptors for HIV?

CCR5 and CXCR4

3

What is gp41? What is its function?

gp41 is a viral protein that mediates fusion of the enveloped virus with the target cell leading to infection.

4

What is the standard indicator of infection with HIV?

Antibodies against the virus coat protein gp120.

5

Symptoms of HIV

low grade fevers and night sweats; excessive fatigue; candidiasis; swollen lymph nodes; weight loss; CD4+ levels dropping; low platelet count

6

What tests do you use to diagnose HIV infection?

Eliza; Western blot

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