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Flashcards in Joint disease Deck (10):
1

Synovial joint cell types

Type A - macrophages containing lyosomes, ensure only synovial fluid is in joint
Type B - secrete hyaluronic acid to lubricate joint

2

OA articular cartilage pathology

Flaking - cartilage - cartilage contact
Fibrillation - articular cartilage starts to flake off
Eburnation - bone-on-bone smoothing of joint, this breaks a lot faster than cartilage and can't be digested by macrophages as too large

3

Causes of arthritis

CaT IN BED
CDH
Trauma
Infective
Neoplastic
Blood/biochemical (gout, haematochromatosis)
Endocrine (diabetes)
Degenerative (overuse)

4

Bacterial infection of bone usually caused by

Staphylococci (streptococci/enterobacteria can in neonates) or TB

5

Acute haematogenous osteomyelitis pathology

Metaphysis usually infected, arteries thrombosed and pus bursts through bone stripping periosteum and vascular supply

6

Tuberculosis osteomyelitis

TB transported in bloodstream, can cause vertebral collapse, normal TB treatment (isoniazid, rifampicin, ethambutol)

7

Cellulitis vs necrotising fasciitis

Cellulitis in sub-dermal fat, necrotising fasciitis in soft tissue below dermis
Caused by anaerobes, strep pyogenes

8

Gas gangrene

usually follows trauma, acute localised pain and hypotension due to gas from bacterial growth and exotoxins
treated with removal of tissue

9

Myasthenia gravis

Autoantibodies to AChR, transient disease as IgG half life is only 3 weeks
Treated with ACh inhibitors, corticosteroids

10

Polymyositis/dermatomyositis

Rare, loss of skeletal muscle with inflammation and auto-antibodies to histidyl-tRNA synthetase
Leads to dermatomyositis in half of patients due to vasculitis