Juvenile Idiopathic Arthritis (Juvenile RA) Flashcards Preview

ICM Infectious Disease > Juvenile Idiopathic Arthritis (Juvenile RA) > Flashcards

Flashcards in Juvenile Idiopathic Arthritis (Juvenile RA) Deck (27):
1

What is Juvenile RA?

An inflammatory arthritis in children

2

How many different forms can it present in?

3

3

What are the three different presentations in JRA?

pauciarticular, polycarticular, systemic onset

4

What is its speculated pathogenesis?

dysregulation of immune response

5

Early nonspecific clinical features?

morning stiffness, irritability, assumption of posture, refusal to walk, fatigue, low grade fever, anorexia

6

What Polyarticular JRA resembles?

Adult RA

7

How many joints are involved in Polyarticular JRA?

5 or more joints

8

What is the pattern of involvement in Poly. JRA?

symmetric or asymmetric, hand involvement like adult RA

9

What joints are commonly involved in JRA?

arthritis of apophyseal joints of spine with stiff neck (check range of motion)

10

Another joint can be involved?

Temporal mandibular joint -> micrognathia

11

How many joints are involved in Oligoarticular JRA?

less than 5 joints

12

What are the joints primarily involved?

knees, ankles, wrists

13

If one joint is involved? It usually is:

Knee

14

How many types in Oligoarticular JRA?

2 types

15

Type I typically present in:

Female, less than 5 years old, >50% ANA +, Uveitis 15-20%

16

Type II typically present in:

Male, late childhood onset, 90% HLA 27+, - RF and - ANA

17

What is the hallmark for Systemic onset JRA?

Quotidian (daily) fever, chills no rigor

18

What makes diagnostic in JRA?

Rash (migratory erthematous macuoles) + fever

19

The rash can be induced by:

rubbing or scratching the skin -> Koebner phenomena

20

What are the extra-articular manifestations of JRA?

pericarditis, myocarditis, chronic uveitis, iridocyclitis, blindness, brachydactly (short fingers), TMJ->microganthia

21

Diganostic criteria includes?

22

Special lab studies and results?

RF (only 20%+), ANA (40%+), CBC (normaocytic/hypchromic anemia and leukocytosis)

23

X-rays result show what following features?

soft tissue swelling, premature closing of epiphysis, marginal erosion, narrowing of cartilage, antlantoaxial subluxation

24

Treatment of JRA?

pain and inflammation relief: NSAIDs, corticosteroids, DMARD (methotrexate, TNF inhibitors)
physical therapy

25

50% of JRA is

Pauciarthritis

26

75% of ANA is

Pauciarthritis

27

Prominent extra-articular involvement

Systemic onset JRA