Katzung 12th ed - Chapter 11 - Antihypertensives (1.8) Flashcards Preview

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Flashcards in Katzung 12th ed - Chapter 11 - Antihypertensives (1.8) Deck (7):
1

Sodium nitroprusside is a vasodilator - which types of vessels does it act on?

Both arterioles and venules.

2

By what route is sodium nitroprusside given?

IV

3

What is the starting dose of sodium nitroprusside? What can this be increased to?

Start at 0.5 mcg / kg / min. Titrate to BP.
Can increase up to 10 mcg / kg / min.

4

What is an important component of sodium nitroprusside that contributes to its toxicity?

Cyanide.

5

Name the potential serious toxic effects of sodium nitroprusside.

Cyanide accumulation, metabolic acidosis, excessive hypotension, arrhythmia, death.

6

Discuss the structure of diazoxide.

The chemical structure of diazoxide is similar to the thiazide drugs, although it has no diuretic activity.

7

What does diazoxide do? How is it given? What is the half-life?

Diazoxide is an arteriolar dilator, given IV to treat hypertensive emergencies (but it is not used much these days). Half-life 24hrs.

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