Flashcards in Katzung 13th ed - Chapter 29 - Antipsychotics (2) Deck (14):
There are two classes of CNS receptors that are stimulated to produce psychosis, and are antagonized by the atypical antipsychotics to prevent psychosis. Which two are these?
Serotonin (5HT2A) receptors and Dopamine (D2) receptors.
Name two classical (typical) antipsychotics that are still in common use today.
What is the key pharmacodynamic feature of the atypical antipsychotics that causes prevention of psychosis?
5HT2A receptor blockade.
What is the key difference in the pharmacodynamic features of typical and atypical antipsychotics, in their mechanism of preventing psychosis?
D2 receptor blockade is greater than 5HT2A receptor blockade
5HT2A receptor blockade is greater than D2 receptor blockade
Name some atypical antipsychotics.
Name some receptors that are antagonized by atypical antipsychotics.
Name some of the extrapyramidal side effects.
Which antipsychotic has the highest extrapyramidal toxicity?
What is the pharmacodynamic feature of antipsychotics that causes extrapyramidal side effects?
D2 receptor blockade.
Describe the adverse effects of antipsychotics.
Alpha-1 antagonism: postural hypotension, tachycardia
Neuroleptic malignant syndrome
What are the features of Neuroleptic Malignant Syndrome?
Describe some basic pharmacokinetics of antipsychotics.
Lipid soluble, highly protein bound (95%), large volume of distribution. Long half-lives. Metabolized in liver and excreted in urine.
What is the most common clinical indication for lithium?
Bipolar affective disorder