Flashcards in Kebbekus- Lymphoma Cases Deck (31):
Describe the staging levels of lymphoma.
1- single LN/organ
2->2 LN on same side of diaphragm
3->2 LN above and below diaphragm
4- widespread disease, multiple organs w/ or without LN involvement
What are lymph tissues?
Waldeyers ring (tonsils and adenoids)
What is the treatment for localized (I/II) stage hodgkins?
ABVD x 2
What is the treatment for III/IV disease?
Intense chemotherapy BEACOPP
What are the possible late effects of therapy?
What second malignancies would you be worried about after therapy for HD?
Solid tumors--lung cancer* and breat cancer
Heart disease is an effect of tx for HD because....
it's associated w/ radtation to mediastinum
What effect of therapy is associated w/ bleomycin containing regimens that are combined w/ chest radiation?
What immunochemistry is associated w/ DLBCL?
Diffuse large b cell lymphoma
CD5-, CD19, CD20, CD23
DLBCL is most common in ....
Prototype for an AGGRESSIVE lymphoma
DLBCL is often treated w/
What do we add to CHOP now that has made a big difference?
How long is CHOP given?
What is the most common INDOLENT NHL?
What percent of Follicular lymphoma cases are at an advanced stage at presentation?
What traaslocation is associated w/ follicular lymphoma?
*BCL-2 is translocated to chromosome 14, comes under control of IgH enhancer which leads to overexpression of Bcl-2
BCL-2 chromosome 18q21 inhibits apoptosis
IgH chromosome 14q32
What CD marker is associated w/ follicular lymphoma?
What is the cure rate for follicular lymphoma? Survival?
survival 10-12 years
What are the indolent B cell lymphomas?
Follicular- most common
LPL or waldenstorm
What are aggressive BCLs?
Mantle cell** could also be put in indolent column
What is a HIGHLY aggressive BCL?
Start chemo right away
associated w/ EBV
What translocation is associated w/ mantle cell lymphoma? Associated w/ what cyclin?
positive for cyclin D1
Heavy chain on 14 and cyclin D1 translocation
Mantle cell lymphoma is positive for what CD?
How do you treat pts w/ advanced mantle cell?
Induced w/ RCHOP
autologous stem cell transplant
What would flow cytometry show for CLL?
Kappa or lambda light chain but NOT both
CD 5, 19, 20, 23
Who should be treated for CLL?
For advanced disease if:
progressive lymphocytosis over 2 motnhs
AIHA and thromobocytopenia
What CDs are characteristic of MALT lymhoma?
MALT is frequently associated w/ what bacteria?
How do you treat MALT?
2-3 rounds of earadication, if no clearing 203 courses XRT and chemo
Post transplant lymphoproliferative disorder is associated w/ what drugs?