What is the key translocation associated with APML
t(15;17) - PML-RARA
What is the key translocation associated with CML
t(9;22) - BCR-ABL
What is the key translocation associated with Burkitt-Lymphoma
t(8;14) - MYC-Ig
What is the key translocation associated with Ewings Sarcoma
t(11;22) - EWS/Fli1
What is the key translocation associated with Infant B-ALL
t(4;11) - MLL rearrangement
What is the key translocation associated with a GOOD prognosis in B-ALL
t(12;21) - ETV6/RUNX1
what translocation is associated with Synovial Sarcoma
t(X;18) - SYT/SSX
what is the key translocation in Follicular lymphoma
t(14;18) - BCL2 / Ig
What are the 3 most common translocations in AML
> APML: t(15;17) - PML/RARA
AML: t(8;21) - RUNX1 / RUNX1T1
inv(16)(p13q22) - CBFB-MYH11
note: both RUNX1 and CBFC make up the CBF classed as a class 2 mutation in leukaemia
