KIDNEYS Flashcards
(45 cards)
Emergent dialysis requirements
Elevated Potassium
Metabolic acidosis
Hypovolemia
Glomerulonephritis
Children, over 60
Chronic
atuoimmune, genetic, or drug use
Nephritic syndrome
Inflammation of glomeruli HTN Hematuria Oliguria Berger's disease (most common cause)
Neprhotic syndrome
Hypoalbuminemia-> albumin excreted, reduction in oncotic pressure-> edema
Hyperlipidemia
Mega proteinuria
Nephrosclerosis
Benign: over 60, Vasc. changes w/ htn/atherosclerosis
Malignant: significant HTN, malignant HTN
Renal Artery Stenosis
Atherosclerosis of renal arteriies
Can be one or both branches
Cause of secondary HTN
Renal Vein Thrombosis:
Basically a DVT in kidneys
Polycystic Kidney Disease (PKD)
4th cause of ESRD
Genetic
Manifestations: Ruptured cysts, HTN, pain/heaviness
May need nephrectomy
Kidney Cancer
Renal cell carcinoma
Male
Smoker
Obese
Family Hx
AKI Acute Kidney Injury
Oliguric Phase
Diuretic Phase
Recovery phase
Oliguric phase (AKI)
Phase 1 of AKI
Oliguria- <400mL/day within 1-7 days of kidney injury
Urinalysis (specific gravity fixated at 1.010)
Metabolic acidosis
Hyperkalemia, Hyponatremia
Elevated BUN and Creatinine
Fatigue, malaise
Diuretic phase (AKI)
Phase 2 of AKI
Gradual inc. in urine output
Hypovolemia, dehydration
Hypotension
BUN and Creatinine normalizes
Recover phase (AKI)
Phase 3 of AKI
GFR increases
BUN and creatinine plateaus and then drops
Risk factors for AKI
Pre-existing kidney disease MODS/sepsis Age Trauma Surgery Burns
Rifle classification of AKI
R: RISK
I: INJURY
F: FAILURE
L: LOSS
E: ESKD
RIFLE (R)
Risk
Serum creatinine 1.5x baseline OR GFR decrease by 25%
Urinary output under .5mL/kg/hr for 6hr
RIFLE (I)
Injury
Creatinine 2x baseline
GFR decreases by 50%
Urinary output:
RIFLE (F)`
Failure
3x baseline serum creatinine
GFR decreases 75%
Or Creatinine aboce 354 umol/L with acute rise of 44umol/L
Urinary output >.3mL/kg/hr for 24hr
or Anuria for 12 hr
RIFLE (L)
Loss
Persistent acute renal failure= complete loss of kidney function for more than 4 weeks
RIFLE (E)
End Stage Kidney Disease for more than 3 months
Pre-renal issue causes
Hypoperufsion: Volume depletion, vascular issues, shock
Decreased filtration (Hypotension): most common in Peds
Cardiac Output: MI, HF
Intrinsic renal issue causes
Glomerular: Acute glomerulonephritis
Vascular: Vasculitis, Atheroemboli, manipulation of aorta
Tubulointerstitial: Acute tubular necrosis
MEDS that can cause pre-renal injury
Ace inhibitors
ARB (Angiotensin II blockers)
NSAIDS
COX-2 inhibitors (celecoxib)
Loop diuretics, thiazide diuretics
Immunomodulators: Cyclosporine
MEDS that can cause ATN (Acute Tubular Necrosis)
Antibiotics
HIV meds
Statin (lovastatin): rhabdomyolysis
Biphosphonates