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Flashcards in Kinins Deck (28):
1

HMG kinongen -----> bradykinin

plasma kallikrein

2

LMW kinogen --------->

kallidin

3

LMW kininogen ------> kallidin by

tissue kallikrein

4

kallidin ---------> bradykinin

aminopeptidase

5

plasma prekallikrein ------> plasma kallikrein

factor 12a

6

kinins -------> active kinin metabolites

carboxypeptidases N and M
Kininases 1

7

bradykinin --------> inactive products

angiotension converting enzyme (ACE)
Kinanase 2

8

Kinogens -------> kinins by

kallikreins

9

Native bradykinin and kallidin activate ________ receptor

B2

10

Bradykinin and kinin active metabolites activate the _________ receptor

B1

11

des-Arg9-bradykinin
des-Arg10-kallidin

kinin active metabolites

12

_______ constitutively expressed in most tissues

B2

13

_______ expressed upon tissue damage and inflammation

B1

14

Activation of B receptors increases synthesis of __________, _________, and ________

prostaglandins
NO
EDHF

15

NSAIDs reduce bradykinin and kallidin induced increases in prostaglandins by inhibiting

COX

16

Corticosteroids reduce prostanglandins by increasing levels of

lipocortin

17

Most important vasodilator peptide in trigeminal system

calcitonin gene related peptide (CGRP)

18

Kinins ___________ to cause edema

increase permeability of microcirculation

19

Kinins cause
vasodilation/vasoconstriction?
Hypertension/hypotension?

Vasodilation
Hypotension

20

Kinins cause ______
Kinins levels (increased/decreased?) in asthma

Bronchospasms
Increased

21

________________ cells release ____________ in response to vagal stimulation and food distention

Enterochromaffin
serotonin

22

Serotonin neurons in ______________ in brain stem project throughout brain and spinal cord

raphe nuclei

23

Serotonin mainly inactivated by ___________

Platelets only express __________

MAO-A
MAO-B

24

5-hydroxyindoleacetic acid is urinary metabolite of

serotonin

25

Cause vasoconstriction of cranial blood vessels

5-HT1D

26

Autoreceptor. Activation inhibits nociceptive trigeminal afferents which controls _________ attacks

5-HT1B
acute migraine

27

Urinary and platelet levels of serotonin __________ during migraine attacks

decrease

28

_____________ are 5-HT 1B/1D receptor agonists that control or reverse __________ attacks

Triptans
acute migraine