Kumar Final Review - GI - AH Flashcards Preview

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Flashcards in Kumar Final Review - GI - AH Deck (40):
1

Appetite stimulants/ suppressants

Stim – GABA, Supres – Serotonin

2

MOA of Dirlotapide?

Selective inhibitor of microsomal triglyceride transfer protein

3

What is another name for Dirlotapide?

Slentrol

4

Centrally acting Emetic drug?

Apomophine Hydrochloride – dogs only

5

What are the classes of anti-emetic drugs acting on the CTZ?

Butyrophenone derivatives, Peripheral 5HT3 serotonin antagonists, NK-1 receptor blockers

6

What drugs are in the Buyrophenoone derivatives category?

Halperidol, Droperidol

7

What drugs are in the peripheral 5HT3 serotonin antagonists group?

Cyproheptadine, Ondansetron

8

Which anti-emetic can be used to treat Chemotherapeutic related emesis?

Ondansetron

9

What drug is a NK-1 receptor blocker?

Maropitant Citrate (Cerenia)

10

What is the MOA of Maropitant Citrate?

Blocks substance P mediated neurotransmission

11

What are the targets for anti-secretory anti-ulcer drugs?

H2 receptor antagonists (Famotidine and Nizatindine) Proton pump inhibitors (Omeprazole) Prostaglandins (Misoprotol)

12

Which of the H2 antagonists is more potent?

Famotidine

13

How is Nazatindine eliminated and who does that help?

Eliminated by kidneys → better for liver Dz patients

14

MOA of Omeprazole

Irreversibly inhibits H/K -ATPase proton pump

15

Adverse reactions of Omeprazole?

Suppression of the acid barrier → Bact. Entry, aspiration pneumonia, hypergastrinemia, inhibit CP450 --> interferes with metabolism of certain drugs

16

Which antacid can be used as a systemic cytoprotective drug?

Sodium Bicarbonate

17

Prostaglandin E1cytoprotective drug?

Misoprostal

18

What does aluminum sucrose sulfate need to work?

Acidic environment. Antacid → no cytoprotective activation

19

What part of bismuth subsalicylate absorbs toxins and what part decreases intestinal secretions (diarrhea)

Bismuth – absorbs toxins, Salicylate – decreases intestinal secretions

20

List the prokinetic drugs increasing GI motility

Bethanechol, metoclopramide, Cisapride, Domperidone

21

MOA of Bethanechol?

Cholinergic agonist → enhances amplitude of contractions through the GIT

22

Classes of drugs that decrease GI motility?

Anti-cholinergic agents, Opiods, Meperidine Congeners

23

List the anti-cholinergic agonists that decrease GI motility

Atropine, Glycopyrrolate

24

List the Opiods that decrease GI motility

Morphine, Meperidine (also improves sphincter tone → do not use in diarrhea from bact. Infections

25

List the Meperidine congeners

Diphenoxylate (lomotil), Loperamide (immodium), Difenoxin, Paregoric

26

GI protecting and Absorbents

Koalin and Pectin, Bismuth Subsalicylate, Activated Charcoal, cholestyramine

27

What do you use activated charcoal for?

ER Tx of poisoning – admin saline laxative 30-45 mins after tx to flush

28

Which GI protectant is a basic anion exchange resin?

Cholestyramine

29

Emollient laxitives

Mineral Oil and Docusate Sodium

30

Bulk forming laxatives

Psyllium Granules

31

Saline Purgatives (osmotic cathartics)

Magnesium sulphate, Sodium Sulfate, Magnesium Hydroxide, Mannitol and sorbitol, Lactulose

32

Irritant cathartics?

Castor Oil and Anthraquinone Purgatives

33

what can be used to treat sand colic in horses?

Psyllium Granules

34

What does castor oil get degraded into by enzymes?

Emolline

35

Tx for retention enemas?

4% solution acetylcysteine

36

Tx for Meconium retention

Docusate sodium, Mineral oil

37

Drugs affecting the liver

Cholagogues (magnesium sulfate) and Choleretics ( Glycocholate, Taurocholate, UDCA)

38

MOA of cholagogues?

Contracts the gall bladder via release of CCK

39

MOA of Choleretics?

Increases bile secretion

40

Drugs to treat frothy bloat

Dimeticon, Poloxalene