L 14-15 Flashcards Preview

Pharmacology Fall 2015 > L 14-15 > Flashcards

Flashcards in L 14-15 Deck (18):
1

Enzymes assoc. with Acetylcholine production/breakdown

Choline acetyltransferase–production
Acetylcholinesterase–breakdown

2

Enzymes assoc. c Catecholamine synth/breakdown

Tyrosine hydroxylase–production
Monoamine Oxidase (MAO)–breakdown

3

Metabolism products of catecholamines

Dopamine-->Homovanillic Acid
Epinephrine-->Metanephrine
Norepinephrine-->Normetanephrine

Epi & NE -->Vanilla Mandelic Acid (VMA)

4

Basics of M1

CNS, Glands
Gq coupled

5

Basics of M2

Heart, S.M., presynaptic
Gi coupled

6

Basics of M3

Primary Muscarinic receptor
Exocrine glands, S.M., Endothelium
Gq coupled

7

Basics of Alpha1

Vasoconstriction (S.M. excitatory)
Gq coupled

8

Basics Alpha2

Presynaptic
Gi coupled
Brain, platelets, S.M.

9

Basics of Beta1

Heart
Gs coupled

10

Basics of Beta2

Heart (minimal)
Lungs (major)
Dilates vessels to muscles including heart
Increases aqueous humor
Gs coupled
Most sensitive to down regulation

11

Basics of Beta3

Lipolysis

12

ANS receptors in Heart

PS: M2-> dec HR, dec Conduction

S: Beta1-> inc HR, inc conduction, inc contractility
Beta2-> small effect, also inc blood flow

13

ANS receptors in Lungs

PS: M3-> bronchoconstriction

S: Beta2-> bronchodilation

14

ANS receptors in Blood Vessels

PS: no innervation, but I.V. Ach has some vasodilation effect

S: Alpha1-> vasoconstriction

15

ANS receptors in Eyes

PS: M3-> Miosis, accomodation, helps evacuate humor

S: Alpha1-> Mydriasis
Beta2-> inc humor

16

ANS receptors in glands

PS: M3-> lacrimation, salivation

S: M1-> sweating
Alpha1-> salivation

17

ANS receptors in GI

PS: M3-> inc motility, inc secretions, relax sphincters

S: Alpha2/Beta2-> relax GI, tighten sphincters
Beta2-> glycogenolysis, INC K+ UPTAKE
Beta3-> lypolysis

18

ANS receptors in GU

PS: M3-> contract bladder, relax sphincters, erection

S: Beta1-> inc renin
Beta2-> relax bladder & uterus
Alpha1-> Ejaculation, tighten sphincters