L 65 Viral Skin DIseases 2, Chicken Pox, Shingles, Parvovirus B19, HHV-6 Flashcards Preview

Micro Exam 6 > L 65 Viral Skin DIseases 2, Chicken Pox, Shingles, Parvovirus B19, HHV-6 > Flashcards

Flashcards in L 65 Viral Skin DIseases 2, Chicken Pox, Shingles, Parvovirus B19, HHV-6 Deck (28):
1

Virus that causes chicken pox and shingles

Varicella-zoster causes both
Type of Herpes virus
Known to come back because they hang out in the nerves
Unique in that sensitive to acyclovir

2

How does VZV infect?

Respiratory or conjunctiva

3

Chickenpox clinical manifestations

Vesicular, pruritic rash, mostly on the trunk, more advanced spread to face
Fever, malaise, headache, neuralgia
Lesions on roof of mouth common
Viremia comes in waves
Prodrome only in older kids and adults

4

VZV reservoir

Humans only reservoir

5

VZV epidemiology

Seasonal winter-spring
Generally kids 5-9 years
Still very present in the community and will infect kids not vaccinated
Very contagious like measles
Incubation 15 days

6

When is kid with chickenpox most contagious?

1-2 days before appearnce of lesions and 4-5 days after

7

Chickenpox diagnosis

Rash and fever
secondary bacterial infections

8

Chickenpox treatment, and specific drug avoidance

No real treatment needed
Aspirin is NOT recommended=>Reyes Syndrome (wait 14 days)
Lotions for itch
VariZig for high risk patients
Acyclovir is effective

9

Chickenpox prevention

Live attenuated virus (Varivax)
Problems: can cause disease in some patients, breakthrough cases (fixed by two doses), may also lead to shingles later!

10

Congenital Varicella Syndrome

Infection of the mother for the first time during pregnancy causes issues with the fetus

11

Meaning of word Zoster

Zoster=belt
Remember that Shingles shows up in dermatomes and in belt-like distributions

12

Shingles Manifestations

Painful lesions: searing, stabbing, burning neuralgic pain in dermatomal distribution, often doesn't cross midline
Pain may precede rash by days to weeks
Redness becomes papules and vesicles
Rash on face, 20% have eye involvement=> corneal damage quickly
Low grade fever and anorexia

13

Shingles Diagnosis

Usually disease of the aged
Patients with altered immune are prone
May not have a one and done recurrence of this infection

14

Shingles treatment

Treat pain
Usually self-limited
Suppress with acyclovir

15

Shingles complications

Neuralgic pain can remain for months

16

Shingles prevention

Zostavax: 40 times larger dose than varivax, only for those already had chickenpox, live attenuated, only for people >50 yr

17

What is sixth disease?

Human Herpes Virus-6
Also called Exanthem Subitum (rash now)

18

Classic presentation of HHV-6

High Fever (2-5 days) followed by rose-colored rash maculopapular of trunk and neck

19

HHV-6 epidemiology

One of the most common and regularly acquired viral infections of childhood

20

HHV-6 Diagnosis

Antibody by EIA
DNA sequence detection

21

HHV-6 treatment/prevention

No treatment
No prevention
No isolation needed

22

What is 5th disease?

Parvovirus B19
Infectious red rash

23

Parvovirus B19 Manifestations

Prodromal illness for several days: fever, headache, malaise, myalgia, respiratory symptoms, N/V

"Slapped Cheek" maculopapular red rash with circumoral sparing. Resolves in 1-2 weeks
May also involve limbs and trunk

Connective Tissue manifestations follow skin eruptions: arthralgia, arthritis in many different joints, adults often have just this symptom

24

Parvovirus characteristics

Humans only
Non-enveloped
No latent stage

25

Parvovirus epidemiology

Only know human parvovirus capable of disease
Incubation 4-7 days
Epidemics late winter and spring
School age kids!

26

Parvovirus complications

Attacks erythroid progenitor cells and causes anemia, prolonged in immunocompromised

Hydrops fetalis

27

Parvovirus diagnosis

Facial rash
Lacey rash on body
B19 IgM antibody

28

Parvovirus treatment and prevention

Most make rapid recovery
NSAIDS