L06-07 Antidepressants Flashcards Preview

Pharmacology III > L06-07 Antidepressants > Flashcards

Flashcards in L06-07 Antidepressants Deck (21):
1

Give the drug class for: citalopram

selective serotonin reuptake inhibitor (SSRI)

2

Give the drug class for: escitalopram

selective serotonin reuptake inhibitor (SSRI)

3

Give the drug class for: fluoxetine

selective serotonin reuptake inhibitor (SSRI)

4

Give the drug class for: paroxetine

selective serotonin reuptake inhibitor (SSRI)

5

Give the drug class for: sertraline

selective serotonin reuptake inhibitor (SSRI)

6

Give the drug class for: desvenlafaxine

selective norepinephrine reuptake inhibitor (SNRI)

7

Give the drug class for: duloxetine

selective norepinephrine reuptake inhibitor (SNRI)

8

Give the drug class for: venlafaxine

selective norepinephrine reuptake inhibitor (SNRI)

9

Give the drug class for: trazodone

5-HT2 antagonist

10

Give the drug class for: amitryptiline

tricyclic antidepressant (TCA)

11

Give the drug class for: imipramine

tricyclic antidepressant (TCA)

12

Give the drug class for: buproprion

tetracyclic/unicyclic agent

13

Give the drug class for: mirtazapine

tetracyclic/unicyclic agent

14

Give the drug class for: phenelzine

monoamine oxidase inhibitor (MAOI)

15

Give the drug class for: selegiline

monoamine oxidase inhibitor (MAOI)

16

Give the drug class for:
lithium

mood stabilizer

17

List the applications for antidepressants.

major depression
all major anxiety disorders
PTSD
OCD
social anxiety disorder
generalized anxiety disorder
panic disorder
pre-menstrual dysphoric disorder
perimenopause
premature ejaculation
eating disorders (i.e., bulimia nervosa)
incontinence
enuresis
smoking cessation

18

What antidepressants are used for pain disorders?

SNRIs and TCAs are used for neuropathic pain, chronic joint and muscle pain, and fibromyalgia.

19

Describe the signs and symptoms of major depression.

depressed mood for > 2 weeks
loss of interest/pleasure in most activities
disturbed sleep and appetite
deficits in cognition and energy
thoughts of guilt, worthlessness, and suicide

20

Describe the relationship between depression and growth factors.

Depression pathophysiology may involve deficient brain-derived neurotrophic factor (BDNF).
Stress and pain decrease levels.
Low levels are present in the CSF of depressed patients.
BDNF may be increased by:
direct infusion
electroconvulsive therapy
chronic activation of monoamine receptors by antidepressants

21

Describe the relationship between neuroendocrine factors and depression.

Neuroendocrine factors are also involved in depression.
Disturbances of the HPA axis are common.
elevated cortisol
failure to suppress ACTH in response to dexamethasone challenge
chronically elevated corticotropin-releasing hormone
Thyroid disorders are present in ~25% of patients.
Diminished thyrotropin release in response to thyrotropin-releasing hormone.
Menopausal and postpartum estrogen deficiency.
severe testosterone deficiency.