L17 - Integration of Innate and Adaptive Flashcards Preview

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Flashcards in L17 - Integration of Innate and Adaptive Deck (18):
1

phases of T-cell activation

  1. recognition phase
  2. activation phase
  3. effector phase
  4. decline
  5. memory

2

how T-cells enter lymphoid organs

  • rolling motion due to interaction between L-selecting (T-cell) and CD34 or GlyCAM (HEV)
  • halting due to interaction between LFA-1 (T-cell) and ICAM-1 (HEV)

3

how T-cells interact with APCs

  • T-cell and APC
  • CD2 and LFA-3
  • LFA-1 and ICAM-1
  • LFA-1 and ICAM-2
  • ICAM-3 and DC-SIGN

4

"first" signal for T-cell activation

interaction between MHC and TCR

5

"second" T-cell activating signal

B7 (APC) with CD28 (T-cell)

6

B7

ligand that binds to CD28 on T-cells and serves as an activating signal

7

CD28

binds to B7 on APCs

8

activation phase (T-cells)

  1. IL-2 and IL-2R production
  2. change in surface molecules
    • VLA-4 (binds to VCAM)
    • CD40L
  3. differentiation into effector T-cells

9

cytokines that promote TH1 differentiation

IL-12

10

cytokines that promote TH2 differentiation

IL-4

11

cytokines produced by TH1 cells

IL-2, IFN-y, TNF

12

cytokines produced by TH2 cells

IL-4, IL-5, IL-10, IL-13

13

CTLA-4

receptor that recognizes B7 to prevent further activation

14

hyper immunoglobulin M (HIM) syndrome

genetic disorder marked by a lack of CD40L, resulting in no T-cell dependent antibody responses

15

ligand that binds to CD28 on T-cells and serves as an activating signal

B7

16

binds to B7 on APCs

CD28

17

receptor that recognizes B7 to prevent further activation

CTLA-4

18

genetic disorder marked by a lack of CD40L, resulting in no T-cell dependent antibody responses

hyper immunoglobulin M (HIM) syndrome