L17 - Integration of Innate and Adaptive Flashcards Preview

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Flashcards in L17 - Integration of Innate and Adaptive Deck (18)
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1
Q

phases of T-cell activation

A
  1. recognition phase
  2. activation phase
  3. effector phase
  4. decline
  5. memory
2
Q

how T-cells enter lymphoid organs

A
  • rolling motion due to interaction between L-selecting (T-cell) and CD34 or GlyCAM (HEV)
  • halting due to interaction between LFA-1 (T-cell) and ICAM-1 (HEV)
3
Q

how T-cells interact with APCs

A
  • T-cell and APC
  • CD2 and LFA-3
  • LFA-1 and ICAM-1
  • LFA-1 and ICAM-2
  • ICAM-3 and DC-SIGN
4
Q

“first” signal for T-cell activation

A

interaction between MHC and TCR

5
Q

“second” T-cell activating signal

A

B7 (APC) with CD28 (T-cell)

6
Q

B7

A

ligand that binds to CD28 on T-cells and serves as an activating signal

7
Q

CD28

A

binds to B7 on APCs

8
Q

activation phase (T-cells)

A
  1. IL-2 and IL-2R production
  2. change in surface molecules
    • VLA-4 (binds to VCAM)
    • CD40L
  3. differentiation into effector T-cells
9
Q

cytokines that promote TH1 differentiation

A

IL-12

10
Q

cytokines that promote TH2 differentiation

A

IL-4

11
Q

cytokines produced by TH1 cells

A

IL-2, IFN-y, TNF

12
Q

cytokines produced by TH2 cells

A

IL-4, IL-5, IL-10, IL-13

13
Q

CTLA-4

A

receptor that recognizes B7 to prevent further activation

14
Q

hyper immunoglobulin M (HIM) syndrome

A

genetic disorder marked by a lack of CD40L, resulting in no T-cell dependent antibody responses

15
Q

ligand that binds to CD28 on T-cells and serves as an activating signal

A

B7

16
Q

binds to B7 on APCs

A

CD28

17
Q

receptor that recognizes B7 to prevent further activation

A

CTLA-4

18
Q

genetic disorder marked by a lack of CD40L, resulting in no T-cell dependent antibody responses

A

hyper immunoglobulin M (HIM) syndrome